PasT of Escherichia coli sustains antibiotic tolerance and aerobic respiration as a bacterial homolog of mitochondrial Coq10

PasT of Escherichia coli sustains antibiotic tolerance and aerobic respiration as a bacterial homolog of mitochondrial Coq10

Abstract Antibiotic‐tolerant persisters are often implicated in treatment failure of chronic and relapsing bacterial infections, but the underlying molecular mechanisms have remained elusive. Controversies revolve around the relative contribution of specific genetic switches called toxin–antitoxin (...

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Bibliographic Details
Main Authors: Cinzia Fino, Martin Vestergaard, Hanne Ingmer, Fabien Pierrel, Kenn Gerdes, Alexander Harms
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:MicrobiologyOpen
Subjects:
antibiotic tolerance
electron transport chain
persistence
toxin–antitoxin
ubiquinone
uropathogenic Escherichia coli
Online Access:https://doi.org/10.1002/mbo3.1064

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