Microfluidic Devices for Drug Delivery Systems and Drug Screening
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates o...
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doaj-e72bc0cb8a6841729928935775cb07cd2020-11-24T23:47:15ZengMDPI AGGenes2073-44252018-02-019210310.3390/genes9020103genes9020103Microfluidic Devices for Drug Delivery Systems and Drug ScreeningSamar Damiati0Uday B. Kompella1Safa A. Damiati2Rimantas Kodzius3Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah 21589, Saudi ArabiaDepartment of Pharmaceutical Sciences, Ophthalmology, and Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USADepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University (KAU), Jeddah 21589, Saudi ArabiaMathematics and Natural Sciences Department, The American University of Iraq, Sulaimani, Sulaymaniyah 46001, IraqMicrofluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates of multiphase fluids, microfluidic technology enables the generation of highly stable, uniform, monodispersed particles with higher encapsulation efficiency. Since the existing preclinical models are inefficient drug screens for predicting clinical outcomes, microfluidic platforms might offer a more rapid and cost-effective alternative. Compared to 2D cell culture systems and in vivo animal models, microfluidic 3D platforms mimic the in vivo cell systems in a simple, inexpensive manner, which allows high throughput and multiplexed drug screening at the cell, organ, and whole-body levels. In this review, the generation of appropriate drug or gene carriers including different particle types using different configurations of microfluidic devices is highlighted. Additionally, this paper discusses the emergence of fabricated microfluidic cell-free protein synthesis systems for potential use at point of care as well as cell-, organ-, and human-on-a-chip models as smart, sensitive, and reproducible platforms, allowing the investigation of the effects of drugs under conditions imitating the biological system.http://www.mdpi.com/2073-4425/9/2/103drug and gene delivery systemsin vitro drug screeningcell-on-a-chiporgan-on-a-chiphuman-on-a-chip |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Samar Damiati Uday B. Kompella Safa A. Damiati Rimantas Kodzius |
spellingShingle |
Samar Damiati Uday B. Kompella Safa A. Damiati Rimantas Kodzius Microfluidic Devices for Drug Delivery Systems and Drug Screening Genes drug and gene delivery systems in vitro drug screening cell-on-a-chip organ-on-a-chip human-on-a-chip |
author_facet |
Samar Damiati Uday B. Kompella Safa A. Damiati Rimantas Kodzius |
author_sort |
Samar Damiati |
title |
Microfluidic Devices for Drug Delivery Systems and Drug Screening |
title_short |
Microfluidic Devices for Drug Delivery Systems and Drug Screening |
title_full |
Microfluidic Devices for Drug Delivery Systems and Drug Screening |
title_fullStr |
Microfluidic Devices for Drug Delivery Systems and Drug Screening |
title_full_unstemmed |
Microfluidic Devices for Drug Delivery Systems and Drug Screening |
title_sort |
microfluidic devices for drug delivery systems and drug screening |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2018-02-01 |
description |
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates of multiphase fluids, microfluidic technology enables the generation of highly stable, uniform, monodispersed particles with higher encapsulation efficiency. Since the existing preclinical models are inefficient drug screens for predicting clinical outcomes, microfluidic platforms might offer a more rapid and cost-effective alternative. Compared to 2D cell culture systems and in vivo animal models, microfluidic 3D platforms mimic the in vivo cell systems in a simple, inexpensive manner, which allows high throughput and multiplexed drug screening at the cell, organ, and whole-body levels. In this review, the generation of appropriate drug or gene carriers including different particle types using different configurations of microfluidic devices is highlighted. Additionally, this paper discusses the emergence of fabricated microfluidic cell-free protein synthesis systems for potential use at point of care as well as cell-, organ-, and human-on-a-chip models as smart, sensitive, and reproducible platforms, allowing the investigation of the effects of drugs under conditions imitating the biological system. |
topic |
drug and gene delivery systems in vitro drug screening cell-on-a-chip organ-on-a-chip human-on-a-chip |
url |
http://www.mdpi.com/2073-4425/9/2/103 |
work_keys_str_mv |
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