Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice
The present study aims to assess the anxiolytic and hypnotic activity of ethanolic extract of Cocculus laurifolius leaf in mice. Anxiolytic activity was observed using behavioral paradigms while hypnotic activity was assessed by sodium pentobarbital induced hypnosis in mice. Animals were treated wi...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Bangladesh Pharmacological Society
2019-02-01
|
Series: | Bangladesh Journal of Pharmacology |
Subjects: | |
Online Access: | https://www.banglajol.info/index.php/BJP/article/view/38093 |
id |
doaj-e73c11c70d4b48c8a28b96f2a2579e39 |
---|---|
record_format |
Article |
spelling |
doaj-e73c11c70d4b48c8a28b96f2a2579e392020-11-25T00:34:20ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882019-02-0114110.3329/bjp.v14i1.38093Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in miceSidra Maqbool0Ishrat Younus1Department of Pharmacology, Faculty of Pharmacy, Hamdard University, Madinat al-Hikmah, Muhammad Bin Qasim Avenue, Karachi, PakistanDepartment of Pharmacology, Faculty of Pharmacy, Hamdard University, Madinat al-Hikmah, Muhammad Bin Qasim Avenue, Karachi, Pakistan The present study aims to assess the anxiolytic and hypnotic activity of ethanolic extract of Cocculus laurifolius leaf in mice. Anxiolytic activity was observed using behavioral paradigms while hypnotic activity was assessed by sodium pentobarbital induced hypnosis in mice. Animals were treated with the extract at dose 200 and 400 mg/kg orally for 30 days. Anxiolytic and hypnotic effect were observed on day 1, 7, 15 and 30 of treatment. Significant increase in the number of entries and time spent in open arm were observed in elevated plus maze. Similar results were observed in light/dark, open field and hole board test. The anxiolytic effect was substantially greater at dose 200 mg/kg in comparison to dose 400 mg/kg. Minimal hypnotic activity was observed with decrease in onset and prolongation in duration of sleep at dose 400 mg/kg, while dose 200 mg/kg did not produce any hypnotic effect. These results showed that the ethanolic extract of C. laurifolius leaf might have potential anxiolytic and hypnotic activity in mice. https://www.banglajol.info/index.php/BJP/article/view/38093AnxietyCocculus laurifoliusHypnosisMouse |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sidra Maqbool Ishrat Younus |
spellingShingle |
Sidra Maqbool Ishrat Younus Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice Bangladesh Journal of Pharmacology Anxiety Cocculus laurifolius Hypnosis Mouse |
author_facet |
Sidra Maqbool Ishrat Younus |
author_sort |
Sidra Maqbool |
title |
Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice |
title_short |
Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice |
title_full |
Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice |
title_fullStr |
Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice |
title_full_unstemmed |
Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice |
title_sort |
anxiolytic and hypnotic effects of cocculus laurifolius leaf extract in mice |
publisher |
Bangladesh Pharmacological Society |
series |
Bangladesh Journal of Pharmacology |
issn |
1991-0088 |
publishDate |
2019-02-01 |
description |
The present study aims to assess the anxiolytic and hypnotic activity of ethanolic extract of Cocculus laurifolius leaf in mice. Anxiolytic activity was observed using behavioral paradigms while hypnotic activity was assessed by sodium pentobarbital induced hypnosis in mice. Animals were treated with the extract at dose 200 and 400 mg/kg orally for 30 days. Anxiolytic and hypnotic effect were observed on day 1, 7, 15 and 30 of treatment. Significant increase in the number of entries and time spent in open arm were observed in elevated plus maze. Similar results were observed in light/dark, open field and hole board test. The anxiolytic effect was substantially greater at dose 200 mg/kg in comparison to dose 400 mg/kg. Minimal hypnotic activity was observed with decrease in onset and prolongation in duration of sleep at dose 400 mg/kg, while dose 200 mg/kg did not produce any hypnotic effect. These results showed that the ethanolic extract of C. laurifolius leaf might have potential anxiolytic and hypnotic activity in mice.
|
topic |
Anxiety Cocculus laurifolius Hypnosis Mouse |
url |
https://www.banglajol.info/index.php/BJP/article/view/38093 |
work_keys_str_mv |
AT sidramaqbool anxiolyticandhypnoticeffectsofcocculuslaurifoliusleafextractinmice AT ishratyounus anxiolyticandhypnoticeffectsofcocculuslaurifoliusleafextractinmice |
_version_ |
1725314028986695680 |