The antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytes

The antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytes

The aim of the present study was to investigate the ability of the antibiotic erythromycin to induce micro­nucleus (MN) frequency and the cytokinesis block proliferation index (CBPI) in human peripheral blood lymphocytes in vitro using the cytokinesis-block micronucleus test (CBMN). Cell cultures we...

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Bibliographic Details
Main Authors: Grujičić D., Stošić Ivana, Milošević-Đorđević Olivera
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2009-01-01
Series:Archives of Biological Sciences
Subjects:
erythromycin
human peripheral blood lymphocytes
in vitro effect
micronucleus test
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2009/0354-46640902179G.pdf
Description
Summary:The aim of the present study was to investigate the ability of the antibiotic erythromycin to induce micro­nucleus (MN) frequency and the cytokinesis block proliferation index (CBPI) in human peripheral blood lymphocytes in vitro using the cytokinesis-block micronucleus test (CBMN). Cell cultures were treated with five different concentrations of erythromycin ranging from 0.68 x 10-4 to 5.45 x 10-4 M. The positive control cells were treated with a known mutagen, mitomycin C (MMC), in a concentration of 1.6 x 10-6 M. None of the tested concentrations of erythromycin significantly changed the average MN frequency or CBPI in PHA-stimulated lymphocytes (p > 0.05).
ISSN:0354-4664

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