The antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytes
The aim of the present study was to investigate the ability of the antibiotic erythromycin to induce micronucleus (MN) frequency and the cytokinesis block proliferation index (CBPI) in human peripheral blood lymphocytes in vitro using the cytokinesis-block micronucleus test (CBMN). Cell cultures we...
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University of Belgrade, University of Novi Sad
2009-01-01
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Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2009/0354-46640902179G.pdf |
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doaj-e7428ffeea8c443c884e4a4ed28a317e2020-11-25T00:25:42ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642009-01-0161217918510.2298/ABS0902179GThe antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytesGrujičić D.Stošić IvanaMilošević-Đorđević OliveraThe aim of the present study was to investigate the ability of the antibiotic erythromycin to induce micronucleus (MN) frequency and the cytokinesis block proliferation index (CBPI) in human peripheral blood lymphocytes in vitro using the cytokinesis-block micronucleus test (CBMN). Cell cultures were treated with five different concentrations of erythromycin ranging from 0.68 x 10-4 to 5.45 x 10-4 M. The positive control cells were treated with a known mutagen, mitomycin C (MMC), in a concentration of 1.6 x 10-6 M. None of the tested concentrations of erythromycin significantly changed the average MN frequency or CBPI in PHA-stimulated lymphocytes (p > 0.05). http://www.doiserbia.nb.rs/img/doi/0354-4664/2009/0354-46640902179G.pdferythromycinhuman peripheral blood lymphocytesin vitro effectmicronucleus test |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Grujičić D. Stošić Ivana Milošević-Đorđević Olivera |
spellingShingle |
Grujičić D. Stošić Ivana Milošević-Đorđević Olivera The antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytes Archives of Biological Sciences erythromycin human peripheral blood lymphocytes in vitro effect micronucleus test |
author_facet |
Grujičić D. Stošić Ivana Milošević-Đorđević Olivera |
author_sort |
Grujičić D. |
title |
The antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytes |
title_short |
The antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytes |
title_full |
The antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytes |
title_fullStr |
The antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytes |
title_full_unstemmed |
The antibiotic erythromycin did not affect micronucleus frequency in human PHA-stimulated lymphocytes |
title_sort |
antibiotic erythromycin did not affect micronucleus frequency in human pha-stimulated lymphocytes |
publisher |
University of Belgrade, University of Novi Sad |
series |
Archives of Biological Sciences |
issn |
0354-4664 |
publishDate |
2009-01-01 |
description |
The aim of the present study was to investigate the ability of the antibiotic erythromycin to induce micronucleus (MN) frequency and the cytokinesis block proliferation index (CBPI) in human peripheral blood lymphocytes in vitro using the cytokinesis-block micronucleus test (CBMN). Cell cultures were treated with five different concentrations of erythromycin ranging from 0.68 x 10-4 to 5.45 x 10-4 M. The positive control cells were treated with a known mutagen, mitomycin C (MMC), in a concentration of 1.6 x 10-6 M. None of the tested concentrations of erythromycin significantly changed the average MN frequency or CBPI in PHA-stimulated lymphocytes (p > 0.05). |
topic |
erythromycin human peripheral blood lymphocytes in vitro effect micronucleus test |
url |
http://www.doiserbia.nb.rs/img/doi/0354-4664/2009/0354-46640902179G.pdf |
work_keys_str_mv |
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