In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into a Pluronic® F127-based polymeric micelle system against Leishmania amazonensis infection

In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into a Pluronic® F127-based polymeric micelle system against Leishmania amazonensis infection

New therapeutic strategies against leishmaniasis are desirable, since the treatment against disease presents problems, such as the toxicity, high cost and/or parasite resistance. As consequence, new antileishmanial compounds are necessary to be identified, as presenting high activity against Leishma...

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Bibliographic Details
Main Authors: Débora V.C. Mendonça, Grasiele S.V. Tavares, Daniela P. Lage, Tauane G. Soyer, Lívia M. Carvalho, Daniel S. Dias, Patrícia A.F. Ribeiro, Flaviano M. Ottoni, Luciana M.R. Antinarelli, Danniele L. Vale, Fernanda Ludolf, Mariana C. Duarte, Elaine S. Coimbra, Miguel A. Chávez-Fumagalli, Bruno M. Roatt, Daniel Menezes-Souza, José Mário Barichello, Ricardo J. Alves, Eduardo A.F. Coelho
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tegumentary leishmaniasis
Chemotherapy
Toxicity
Amphotericin B
Pluronic®F127
2-(2,3,4-Tri-O-acetyl-6-deoxy-β-l-galactopyranosyloxy)-1,4-naphthoquinone
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218367878

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http://www.sciencedirect.com/science/article/pii/S0753332218367878

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