Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

Ghrelin is a gastric peptide hormone with important physiological functions, including growth hormone release and appetite-stimulating activity. Here, authors solved the crystal structure of the ghrelin receptor bound to antagonist and suggested a possible mechanism of activation by acyl-modified gh...

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Main Authors:	Yuki Shiimura, Shoichiro Horita, Akie Hamamoto, Hidetsugu Asada, Kunio Hirata, Misuzu Tanaka, Kenji Mori, Tomoko Uemura, Takuya Kobayashi, So Iwata, Masayasu Kojima
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17554-1

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spelling	doaj-e7526d5cb5754366b7a2d14fcf34c3e12021-08-22T11:41:10ZengNature Publishing GroupNature Communications2041-17232020-08-011111910.1038/s41467-020-17554-1Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition modeYuki Shiimura0Shoichiro Horita1Akie Hamamoto2Hidetsugu Asada3Kunio Hirata4Misuzu Tanaka5Kenji Mori6Tomoko Uemura7Takuya Kobayashi8So Iwata9Masayasu Kojima10Division of Molecular Genetics, Institute of Life Science, Kurume UniversityDepartment of Cell Biology, Graduate School of Medicine, Kyoto UniversityDivision of Molecular Genetics, Institute of Life Science, Kurume UniversityDepartment of Cell Biology, Graduate School of Medicine, Kyoto UniversityRIKENDivision of Molecular Genetics, Institute of Life Science, Kurume UniversityDepartment of Biochemistry, National Cerebral and Cardiovascular Center Research InstituteDepartment of Cell Biology, Graduate School of Medicine, Kyoto UniversityDepartment of Cell Biology, Graduate School of Medicine, Kyoto UniversityDepartment of Cell Biology, Graduate School of Medicine, Kyoto UniversityDivision of Molecular Genetics, Institute of Life Science, Kurume UniversityGhrelin is a gastric peptide hormone with important physiological functions, including growth hormone release and appetite-stimulating activity. Here, authors solved the crystal structure of the ghrelin receptor bound to antagonist and suggested a possible mechanism of activation by acyl-modified ghrelin.https://doi.org/10.1038/s41467-020-17554-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuki Shiimura Shoichiro Horita Akie Hamamoto Hidetsugu Asada Kunio Hirata Misuzu Tanaka Kenji Mori Tomoko Uemura Takuya Kobayashi So Iwata Masayasu Kojima
spellingShingle	Yuki Shiimura Shoichiro Horita Akie Hamamoto Hidetsugu Asada Kunio Hirata Misuzu Tanaka Kenji Mori Tomoko Uemura Takuya Kobayashi So Iwata Masayasu Kojima Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode Nature Communications
author_facet	Yuki Shiimura Shoichiro Horita Akie Hamamoto Hidetsugu Asada Kunio Hirata Misuzu Tanaka Kenji Mori Tomoko Uemura Takuya Kobayashi So Iwata Masayasu Kojima
author_sort	Yuki Shiimura
title	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_short	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_full	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_fullStr	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_full_unstemmed	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_sort	structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-08-01
description	Ghrelin is a gastric peptide hormone with important physiological functions, including growth hormone release and appetite-stimulating activity. Here, authors solved the crystal structure of the ghrelin receptor bound to antagonist and suggested a possible mechanism of activation by acyl-modified ghrelin.
url	https://doi.org/10.1038/s41467-020-17554-1
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Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

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