Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models
The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees...
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| Language: | English |
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MDPI AG
2010-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/3/1223/ |
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doaj-e75754c05ead4b368ad7ea601a96cf772020-11-25T01:10:19ZengMDPI AGMolecules1420-30492010-03-011531223123110.3390/molecules15031223Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental ModelsKarel ŠmejkalTereza ŠlapetováPavel KrmenčíkRenata KubínováPavel SuchýStefano Dall´AcquaGabbriella InnocentiJán VančoKarolína KalvarováMargita DvorskáJiří SlaninaEva KramářováJan MuselíkMilan ŽemličkaThe in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested. http://www.mdpi.com/1420-3049/15/3/1223/Schisandra chinensisdibenzocyclooctadiene lignansantiradicaldiabetes mellitus |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Karel Šmejkal Tereza Šlapetová Pavel Krmenčík Renata Kubínová Pavel Suchý Stefano Dall´Acqua Gabbriella Innocenti Ján Vančo Karolína Kalvarová Margita Dvorská Jiří Slanina Eva Kramářová Jan Muselík Milan Žemlička |
| spellingShingle |
Karel Šmejkal Tereza Šlapetová Pavel Krmenčík Renata Kubínová Pavel Suchý Stefano Dall´Acqua Gabbriella Innocenti Ján Vančo Karolína Kalvarová Margita Dvorská Jiří Slanina Eva Kramářová Jan Muselík Milan Žemlička Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models Molecules Schisandra chinensis dibenzocyclooctadiene lignans antiradical diabetes mellitus |
| author_facet |
Karel Šmejkal Tereza Šlapetová Pavel Krmenčík Renata Kubínová Pavel Suchý Stefano Dall´Acqua Gabbriella Innocenti Ján Vančo Karolína Kalvarová Margita Dvorská Jiří Slanina Eva Kramářová Jan Muselík Milan Žemlička |
| author_sort |
Karel Šmejkal |
| title |
Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models |
| title_short |
Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models |
| title_full |
Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models |
| title_fullStr |
Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models |
| title_full_unstemmed |
Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models |
| title_sort |
evaluation of the antiradical activity of schisandra chinensis lignans using different experimental models |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2010-03-01 |
| description |
The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested. |
| topic |
Schisandra chinensis dibenzocyclooctadiene lignans antiradical diabetes mellitus |
| url |
http://www.mdpi.com/1420-3049/15/3/1223/ |
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