A Review of the Role of Wnt in Cancer Immunomodulation
Alterations in the Wnt signaling pathway are associated with the advancement of cancers; however, the exact mechanisms responsible remain largely unknown. It has recently been established that heightened intratumoral Wnt signaling correlates with tumor immunomodulation and immune suppression, which...
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2019-06-01
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Online Access: | https://www.mdpi.com/2072-6694/11/6/771 |
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doaj-e75b5e7f5256433dbd059efc309641b12020-11-25T01:30:25ZengMDPI AGCancers2072-66942019-06-0111677110.3390/cancers11060771cancers11060771A Review of the Role of Wnt in Cancer ImmunomodulationWhitney N. Goldsberry0Angelina Londoño1Troy D. Randall2Lyse A. Norian3Rebecca C. Arend4Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294, USADivision of Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Nutritional Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294, USAAlterations in the Wnt signaling pathway are associated with the advancement of cancers; however, the exact mechanisms responsible remain largely unknown. It has recently been established that heightened intratumoral Wnt signaling correlates with tumor immunomodulation and immune suppression, which likely contribute to the decreased efficacy of multiple cancer therapeutics. Here, we review available literature pertaining to connections between Wnt pathway activation in the tumor microenvironment and local immunomodulation. We focus specifically on preclinical and clinical data supporting the hypothesis that strategies targeting Wnt signaling could act as adjuncts for cancer therapy, either in combination with chemotherapy or immunotherapy, in a variety of tumor types.https://www.mdpi.com/2072-6694/11/6/771Wntβ-cateninimmunomodulationcancerimmunotherapytumor microenvironment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Whitney N. Goldsberry Angelina Londoño Troy D. Randall Lyse A. Norian Rebecca C. Arend |
spellingShingle |
Whitney N. Goldsberry Angelina Londoño Troy D. Randall Lyse A. Norian Rebecca C. Arend A Review of the Role of Wnt in Cancer Immunomodulation Cancers Wnt β-catenin immunomodulation cancer immunotherapy tumor microenvironment |
author_facet |
Whitney N. Goldsberry Angelina Londoño Troy D. Randall Lyse A. Norian Rebecca C. Arend |
author_sort |
Whitney N. Goldsberry |
title |
A Review of the Role of Wnt in Cancer Immunomodulation |
title_short |
A Review of the Role of Wnt in Cancer Immunomodulation |
title_full |
A Review of the Role of Wnt in Cancer Immunomodulation |
title_fullStr |
A Review of the Role of Wnt in Cancer Immunomodulation |
title_full_unstemmed |
A Review of the Role of Wnt in Cancer Immunomodulation |
title_sort |
review of the role of wnt in cancer immunomodulation |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2019-06-01 |
description |
Alterations in the Wnt signaling pathway are associated with the advancement of cancers; however, the exact mechanisms responsible remain largely unknown. It has recently been established that heightened intratumoral Wnt signaling correlates with tumor immunomodulation and immune suppression, which likely contribute to the decreased efficacy of multiple cancer therapeutics. Here, we review available literature pertaining to connections between Wnt pathway activation in the tumor microenvironment and local immunomodulation. We focus specifically on preclinical and clinical data supporting the hypothesis that strategies targeting Wnt signaling could act as adjuncts for cancer therapy, either in combination with chemotherapy or immunotherapy, in a variety of tumor types. |
topic |
Wnt β-catenin immunomodulation cancer immunotherapy tumor microenvironment |
url |
https://www.mdpi.com/2072-6694/11/6/771 |
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