Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle
Calorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However, less is known regarding the effects of CR on these factors in humans. Serum cortisol and molecular chaperones and autophagic proteins were measured in...
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doaj-e75edb8357a9404cb260dbdd272cd4582020-11-25T01:38:54ZengElsevierCell Reports2211-12472016-01-0114342242810.1016/j.celrep.2015.12.042Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal MuscleLing Yang0Danilo Licastro1Edda Cava2Nicola Veronese3Francesco Spelta4Wanda Rizza5Beatrice Bertozzi6Dennis T. Villareal7Gökhan S. Hotamisligil8John O. Holloszy9Luigi Fontana10Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USACBM Scrl—Genomics, Area Science Park, Basovizza, 34149 Trieste, ItalyDivision of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USADivision of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USACalorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However, less is known regarding the effects of CR on these factors in humans. Serum cortisol and molecular chaperones and autophagic proteins were measured in the skeletal muscle of subjects on CR diets for 3–15 years and in control volunteers. Serum cortisol was higher in the CR group than in age-matched sedentary and endurance athlete groups (15.6 ± 4.6 ng/dl versus 12.3 ± 3.9 ng/dl and 11.2 ± 2.7 ng/dl, respectively; p ≤ 0.001). HSP70, Grp78, beclin-1, and LC3 mRNA and/or protein levels were higher in the skeletal muscle of the CR group compared to controls. Our data indicate that CR in humans is associated with sustained rises in serum cortisol, reduced inflammation, and increases in key molecular chaperones and autophagic mediators involved in cellular protein quality control and removal of dysfunctional proteins and organelles.http://www.sciencedirect.com/science/article/pii/S2211124715014837calorie restrictioncortisolaldosteroneHSP70autophagy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ling Yang Danilo Licastro Edda Cava Nicola Veronese Francesco Spelta Wanda Rizza Beatrice Bertozzi Dennis T. Villareal Gökhan S. Hotamisligil John O. Holloszy Luigi Fontana |
spellingShingle |
Ling Yang Danilo Licastro Edda Cava Nicola Veronese Francesco Spelta Wanda Rizza Beatrice Bertozzi Dennis T. Villareal Gökhan S. Hotamisligil John O. Holloszy Luigi Fontana Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle Cell Reports calorie restriction cortisol aldosterone HSP70 autophagy |
author_facet |
Ling Yang Danilo Licastro Edda Cava Nicola Veronese Francesco Spelta Wanda Rizza Beatrice Bertozzi Dennis T. Villareal Gökhan S. Hotamisligil John O. Holloszy Luigi Fontana |
author_sort |
Ling Yang |
title |
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle |
title_short |
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle |
title_full |
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle |
title_fullStr |
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle |
title_full_unstemmed |
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle |
title_sort |
long-term calorie restriction enhances cellular quality-control processes in human skeletal muscle |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2016-01-01 |
description |
Calorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However, less is known regarding the effects of CR on these factors in humans. Serum cortisol and molecular chaperones and autophagic proteins were measured in the skeletal muscle of subjects on CR diets for 3–15 years and in control volunteers. Serum cortisol was higher in the CR group than in age-matched sedentary and endurance athlete groups (15.6 ± 4.6 ng/dl versus 12.3 ± 3.9 ng/dl and 11.2 ± 2.7 ng/dl, respectively; p ≤ 0.001). HSP70, Grp78, beclin-1, and LC3 mRNA and/or protein levels were higher in the skeletal muscle of the CR group compared to controls. Our data indicate that CR in humans is associated with sustained rises in serum cortisol, reduced inflammation, and increases in key molecular chaperones and autophagic mediators involved in cellular protein quality control and removal of dysfunctional proteins and organelles. |
topic |
calorie restriction cortisol aldosterone HSP70 autophagy |
url |
http://www.sciencedirect.com/science/article/pii/S2211124715014837 |
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