The future of viral hepatitis testing: innovations in testing technologies and approaches
Abstract A large burden of undiagnosed hepatitis virus cases remains globally. Despite the 257 million people living with chronic hepatitis B virus infection, and 71 million with chronic viraemic HCV infection, most people with hepatitis remain unaware of their infection. Advances in rapid detection...
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doaj-e7627c881f934ff8a1a489de1f6679442020-11-25T03:55:12ZengBMCBMC Infectious Diseases1471-23342017-11-0117S118719610.1186/s12879-017-2775-0The future of viral hepatitis testing: innovations in testing technologies and approachesRosanna W. Peeling0Debrah I. Boeras1Francesco Marinucci2Philippa Easterbrook3Depart of Clinical Research and International Diagnostics Centre, London School of Hygiene and Tropical MedicineDepart of Clinical Research and International Diagnostics Centre, London School of Hygiene and Tropical MedicineFoundation for Innovative New DiagnosticsGlobal Hepatitis Programme, HIV Department, World Health OrganizationAbstract A large burden of undiagnosed hepatitis virus cases remains globally. Despite the 257 million people living with chronic hepatitis B virus infection, and 71 million with chronic viraemic HCV infection, most people with hepatitis remain unaware of their infection. Advances in rapid detection technology have created new opportunities for enhancing access to testing and care, as well as monitoring of treatment. This article examines a range of other technological innovations that can be leveraged to provide more affordable and simplified approaches to testing for HBV and HCV infection and monitoring of treatment response. These include improved access to testing through alternative sampling methods (use of dried blood spots, oral fluids, self-testing) and combination rapid diagnostic tests for detection of HIV, HBV and HCV infection; more affordable options for confirmation of virological infection (HBV DNA and HCV RNA) such as point-of-care molecular assays, HCV core antigen and multi-disease polyvalent molecular platforms that make use of existing centralised laboratory based or decentralised TB and HIV instrumentation for viral hepatitis testing; and finally health system improvements such as integration of laboratory services for procurement and sample transportation and enhanced data connectivity to support quality assurance and supply chain management.http://link.springer.com/article/10.1186/s12879-017-2775-0Hepatitis B virusHepatitis C virusPoint-of-careDiagnostic testLow resource settingsWHO |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosanna W. Peeling Debrah I. Boeras Francesco Marinucci Philippa Easterbrook |
spellingShingle |
Rosanna W. Peeling Debrah I. Boeras Francesco Marinucci Philippa Easterbrook The future of viral hepatitis testing: innovations in testing technologies and approaches BMC Infectious Diseases Hepatitis B virus Hepatitis C virus Point-of-care Diagnostic test Low resource settings WHO |
author_facet |
Rosanna W. Peeling Debrah I. Boeras Francesco Marinucci Philippa Easterbrook |
author_sort |
Rosanna W. Peeling |
title |
The future of viral hepatitis testing: innovations in testing technologies and approaches |
title_short |
The future of viral hepatitis testing: innovations in testing technologies and approaches |
title_full |
The future of viral hepatitis testing: innovations in testing technologies and approaches |
title_fullStr |
The future of viral hepatitis testing: innovations in testing technologies and approaches |
title_full_unstemmed |
The future of viral hepatitis testing: innovations in testing technologies and approaches |
title_sort |
future of viral hepatitis testing: innovations in testing technologies and approaches |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2017-11-01 |
description |
Abstract A large burden of undiagnosed hepatitis virus cases remains globally. Despite the 257 million people living with chronic hepatitis B virus infection, and 71 million with chronic viraemic HCV infection, most people with hepatitis remain unaware of their infection. Advances in rapid detection technology have created new opportunities for enhancing access to testing and care, as well as monitoring of treatment. This article examines a range of other technological innovations that can be leveraged to provide more affordable and simplified approaches to testing for HBV and HCV infection and monitoring of treatment response. These include improved access to testing through alternative sampling methods (use of dried blood spots, oral fluids, self-testing) and combination rapid diagnostic tests for detection of HIV, HBV and HCV infection; more affordable options for confirmation of virological infection (HBV DNA and HCV RNA) such as point-of-care molecular assays, HCV core antigen and multi-disease polyvalent molecular platforms that make use of existing centralised laboratory based or decentralised TB and HIV instrumentation for viral hepatitis testing; and finally health system improvements such as integration of laboratory services for procurement and sample transportation and enhanced data connectivity to support quality assurance and supply chain management. |
topic |
Hepatitis B virus Hepatitis C virus Point-of-care Diagnostic test Low resource settings WHO |
url |
http://link.springer.com/article/10.1186/s12879-017-2775-0 |
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