A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus <i>Penicillium citrinum</i>
Sponge-associated fungi are attractive targets for the isolation of bioactive natural products with different pharmaceutical purposes. In this investigation, 20 fungi were isolated from 10 different sponge specimens. One isolate, the fungus <i>Penicillium citrinum</i> strain WK-P9, showe...
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MDPI AG
2020-04-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/4/227 |
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doaj-e764a612cba04a57a442b6cbc90996832020-11-25T02:47:48ZengMDPI AGMarine Drugs1660-33972020-04-011822722710.3390/md18040227A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus <i>Penicillium citrinum</i>Aninditia Sabdaningsih0Yang Liu1Ute Mettal2John Heep3Riyanti4Lei Wang5Olvi Cristianawati6Handung Nuryadi7Mada Triandala Sibero8Michael Marner9Ocky Karna Radjasa10Agus Sabdono11Agus Trianto12Till F. Schäberle13Department of Coastal Resources Management, Faculty of Fisheries and Marine Sciences, Diponegoro University, Semarang 50275, IndonesiaInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, 35392 Giessen, GermanyInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, 35392 Giessen, GermanyDepartment of Bioresources of the Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), 35392 Giessen, GermanyInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, 35392 Giessen, GermanyInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, 35392 Giessen, GermanyDepartment of Coastal Resources Management, Faculty of Fisheries and Marine Sciences, Diponegoro University, Semarang 50275, IndonesiaTropical Marine Biotechnology Laboratory, Diponegoro University, Semarang 50275, IndonesiaTropical Marine Biotechnology Laboratory, Diponegoro University, Semarang 50275, IndonesiaDepartment of Bioresources of the Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), 35392 Giessen, GermanyTropical Marine Biotechnology Laboratory, Diponegoro University, Semarang 50275, IndonesiaTropical Marine Biotechnology Laboratory, Diponegoro University, Semarang 50275, IndonesiaMarine Natural Product Laboratory, Diponegoro University, Semarang 50275, IndonesiaInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, 35392 Giessen, GermanySponge-associated fungi are attractive targets for the isolation of bioactive natural products with different pharmaceutical purposes. In this investigation, 20 fungi were isolated from 10 different sponge specimens. One isolate, the fungus <i>Penicillium citrinum</i> strain WK-P9, showed activity against <i>Bacillus subtilis</i> JH642 when cultivated in malt extract medium. One new and three known citrinin derivatives were isolated from the extract of this fungus. The structures were elucidated by 1D and 2D NMR spectroscopy, as well as LC-HRMS. Their antibacterial activity against a set of common human pathogenic bacteria and fungi was tested. Compound <b>2</b> showed moderate activity against <i>Mycobacterium smegmatis</i> ATCC607 with a minimum inhibitory concentration (MIC) of 32 µg/mL. Compound <b>4</b> exhibited moderate growth inhibition against <i>Bacillus subtilis</i> JH642, <i>B. megaterium</i> DSM32, and <i>M. smegmatis</i> ATCC607 with MICs of 16, 16, and 32 µg/mL, respectively. Furthermore, weak activities of 64 µg/mL against <i>B. subtilis</i> DSM10 and <i>S. aureus</i> ATCC25923 were observed for compound <b>4</b>.https://www.mdpi.com/1660-3397/18/4/227antibacterialcitrinin derivativesmarine-derived fungi<i>Penicillium citrinum</i>penicitrinonemarine sponges |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Aninditia Sabdaningsih Yang Liu Ute Mettal John Heep Riyanti Lei Wang Olvi Cristianawati Handung Nuryadi Mada Triandala Sibero Michael Marner Ocky Karna Radjasa Agus Sabdono Agus Trianto Till F. Schäberle |
| spellingShingle |
Aninditia Sabdaningsih Yang Liu Ute Mettal John Heep Riyanti Lei Wang Olvi Cristianawati Handung Nuryadi Mada Triandala Sibero Michael Marner Ocky Karna Radjasa Agus Sabdono Agus Trianto Till F. Schäberle A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus <i>Penicillium citrinum</i> Marine Drugs antibacterial citrinin derivatives marine-derived fungi <i>Penicillium citrinum</i> penicitrinone marine sponges |
| author_facet |
Aninditia Sabdaningsih Yang Liu Ute Mettal John Heep Riyanti Lei Wang Olvi Cristianawati Handung Nuryadi Mada Triandala Sibero Michael Marner Ocky Karna Radjasa Agus Sabdono Agus Trianto Till F. Schäberle |
| author_sort |
Aninditia Sabdaningsih |
| title |
A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus <i>Penicillium citrinum</i> |
| title_short |
A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus <i>Penicillium citrinum</i> |
| title_full |
A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus <i>Penicillium citrinum</i> |
| title_fullStr |
A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus <i>Penicillium citrinum</i> |
| title_full_unstemmed |
A New Citrinin Derivative from the Indonesian Marine Sponge-Associated Fungus <i>Penicillium citrinum</i> |
| title_sort |
new citrinin derivative from the indonesian marine sponge-associated fungus <i>penicillium citrinum</i> |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2020-04-01 |
| description |
Sponge-associated fungi are attractive targets for the isolation of bioactive natural products with different pharmaceutical purposes. In this investigation, 20 fungi were isolated from 10 different sponge specimens. One isolate, the fungus <i>Penicillium citrinum</i> strain WK-P9, showed activity against <i>Bacillus subtilis</i> JH642 when cultivated in malt extract medium. One new and three known citrinin derivatives were isolated from the extract of this fungus. The structures were elucidated by 1D and 2D NMR spectroscopy, as well as LC-HRMS. Their antibacterial activity against a set of common human pathogenic bacteria and fungi was tested. Compound <b>2</b> showed moderate activity against <i>Mycobacterium smegmatis</i> ATCC607 with a minimum inhibitory concentration (MIC) of 32 µg/mL. Compound <b>4</b> exhibited moderate growth inhibition against <i>Bacillus subtilis</i> JH642, <i>B. megaterium</i> DSM32, and <i>M. smegmatis</i> ATCC607 with MICs of 16, 16, and 32 µg/mL, respectively. Furthermore, weak activities of 64 µg/mL against <i>B. subtilis</i> DSM10 and <i>S. aureus</i> ATCC25923 were observed for compound <b>4</b>. |
| topic |
antibacterial citrinin derivatives marine-derived fungi <i>Penicillium citrinum</i> penicitrinone marine sponges |
| url |
https://www.mdpi.com/1660-3397/18/4/227 |
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