Anti-inflammatory effect of Fumaria parviflora leaves based on TNF-α, IL-1, IL-6 and antioxidant potential

Anti-inflammatory effect of Fumaria parviflora leaves based on TNF-α, IL-1, IL-6 and antioxidant potential

Objective: In this study, we evaluated anti-inflammatory activity of leaves of Fumaria parviflora (F. parviflora) and underlying mechanisms by using in vivo models of inflammation.Material and Methods: Albino Wistar rats of either sex weighing 150 - 200 g were used. Soxhlet ethanol and aqueous extra...

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Bibliographic Details
Main Authors: Waseem Rizvi, Mohammad Fayazuddin, Ompal Singh, Shariq Naeem, Shagufta Moin, Kafil Akhtar, Anil Kumar
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2017-01-01
Series:Avicenna Journal of Phytomedicine
Subjects:
Fumeria
Carrageenan
Cytokines
Antioxidant
Anti-inflammatory
Online Access:http://ajp.mums.ac.ir/article_6955_1ebb91289ebe79b9148970e3ef5a2884.pdf
Description
Summary:Objective: In this study, we evaluated anti-inflammatory activity of leaves of Fumaria parviflora (F. parviflora) and underlying mechanisms by using in vivo models of inflammation.Material and Methods: Albino Wistar rats of either sex weighing 150 - 200 g were used. Soxhlet ethanol and aqueous extracts of leaves of F. parviflora (EFP and AFP) were prepared. The anti-inflammatory activity was studied using carrageenan-induced paw edema method and cotton pellet granuloma method. Levels of cytokines such as TNF-α, IL-6 and IL-1 and activity of antioxidant enzymes including catalase (CAT) and glutathione peroxidase (GPx) were estimated.Results: Leaves of F. parviflora demonstrated significant (p
ISSN:2228-7930
2228-7949

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