Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of Ailanthus altissima

Phytochemistry investigations on Ailanthus altissima (Mill.) Swingle, a Simaroubaceae plant that is recognized as a traditional herbal medicine, have afforded various natural products, among which C20 quassinoid is the most attractive for their significant a...

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Main Authors:	Qing-Wei Tan, Jian-Cheng Ni, Jian-Ting Shi, Jian-Xuan Zhu, Qi-Jian Chen
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	Molecules
Subjects:	<i>Ailanthus altissima</i> (Mill.) Swingle Simaroubaceae quassinoid lignanoid tobacco mosaic virus
Online Access:	https://www.mdpi.com/1420-3049/25/23/5679

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spelling	doaj-e776400b0d62408b800c69a1bc4ba9be2020-12-03T00:00:09ZengMDPI AGMolecules1420-30492020-12-01255679567910.3390/molecules25235679Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of <i>Ailanthus altissima</i>Qing-Wei Tan0Jian-Cheng Ni1Jian-Ting Shi2Jian-Xuan Zhu3Qi-Jian Chen4Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaThe Engineering Technology Research Center of Characteristic Medicinal Plants of Fujian, Ningde Normal University, Ningde 352100, ChinaKey Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaKey Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaKey Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaPhytochemistry investigations on <i>Ailanthus altissima</i> (Mill.) Swingle, a Simaroubaceae plant that is recognized as a traditional herbal medicine, have afforded various natural products, among which C<sub>20</sub> quassinoid is the most attractive for their significant and diverse pharmacological and biological activities. Our continuous study has led to the isolation of two novel quassinoid glycosides, named chuglycosides J and K, together with fourteen known lignans from the samara of <i>A. altissima</i>. The new structures were elucidated based on comprehensive spectra data analysis. All of the compounds were evaluated for their anti-tobacco mosaic virus activity, among which chuglycosides J and K exhibited inhibitory effects against the virus multiplication with half maximal inhibitory concentration (IC<sub>50</sub>) values of 56.21 ± 1.86 and 137.74 ± 3.57 μM, respectively.https://www.mdpi.com/1420-3049/25/23/5679<i>Ailanthus altissima</i> (Mill.) SwingleSimaroubaceaequassinoidlignanoidtobacco mosaic virus
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qing-Wei Tan Jian-Cheng Ni Jian-Ting Shi Jian-Xuan Zhu Qi-Jian Chen
spellingShingle	Qing-Wei Tan Jian-Cheng Ni Jian-Ting Shi Jian-Xuan Zhu Qi-Jian Chen Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of <i>Ailanthus altissima</i> Molecules <i>Ailanthus altissima</i> (Mill.) Swingle Simaroubaceae quassinoid lignanoid tobacco mosaic virus
author_facet	Qing-Wei Tan Jian-Cheng Ni Jian-Ting Shi Jian-Xuan Zhu Qi-Jian Chen
author_sort	Qing-Wei Tan
title	Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of <i>Ailanthus altissima</i>
title_short	Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of <i>Ailanthus altissima</i>
title_full	Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of <i>Ailanthus altissima</i>
title_fullStr	Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of <i>Ailanthus altissima</i>
title_full_unstemmed	Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of <i>Ailanthus altissima</i>
title_sort	two novel quassinoid glycosides with antiviral activity from the samara of <i>ailanthus altissima</i>
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2020-12-01
description	Phytochemistry investigations on <i>Ailanthus altissima</i> (Mill.) Swingle, a Simaroubaceae plant that is recognized as a traditional herbal medicine, have afforded various natural products, among which C<sub>20</sub> quassinoid is the most attractive for their significant and diverse pharmacological and biological activities. Our continuous study has led to the isolation of two novel quassinoid glycosides, named chuglycosides J and K, together with fourteen known lignans from the samara of <i>A. altissima</i>. The new structures were elucidated based on comprehensive spectra data analysis. All of the compounds were evaluated for their anti-tobacco mosaic virus activity, among which chuglycosides J and K exhibited inhibitory effects against the virus multiplication with half maximal inhibitory concentration (IC<sub>50</sub>) values of 56.21 ± 1.86 and 137.74 ± 3.57 μM, respectively.
topic	<i>Ailanthus altissima</i> (Mill.) Swingle Simaroubaceae quassinoid lignanoid tobacco mosaic virus
url	https://www.mdpi.com/1420-3049/25/23/5679
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Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of <i>Ailanthus altissima</i>

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