Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses

Abstract Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate aroun...

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Main Authors:	Ming-Hsiang Hong, I-Chun Weng, Fang-Yen Li, Wei-Han Lin, Fu-Tong Liu
Format:	Article
Language:	English
Published:	BMC 2021-03-01
Series:	Journal of Biomedical Science
Subjects:	Galectin Carbohydrates Glycans Infection Autophagy
Online Access:	https://doi.org/10.1186/s12929-021-00713-x

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spelling	doaj-e78019caffa44fdf9c0fa6f1dd6a9e402021-03-11T11:57:36ZengBMCJournal of Biomedical Science1423-01272021-03-012811910.1186/s12929-021-00713-xIntracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responsesMing-Hsiang Hong0I-Chun Weng1Fang-Yen Li2Wei-Han Lin3Fu-Tong Liu4Institute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaAbstract Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate around these damaged organelles. Accumulated galectins then engage cellular proteins and subsequently control cellular responses, such as autophagy. In this review, we have summarized the stimuli that lead to the accumulation of galectins, the molecular mechanisms of galectin accumulation, and galectin-mediated cellular responses, and elaborate on the differential regulatory effects among galectins.https://doi.org/10.1186/s12929-021-00713-xGalectinCarbohydratesGlycansInfectionAutophagy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ming-Hsiang Hong I-Chun Weng Fang-Yen Li Wei-Han Lin Fu-Tong Liu
spellingShingle	Ming-Hsiang Hong I-Chun Weng Fang-Yen Li Wei-Han Lin Fu-Tong Liu Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses Journal of Biomedical Science Galectin Carbohydrates Glycans Infection Autophagy
author_facet	Ming-Hsiang Hong I-Chun Weng Fang-Yen Li Wei-Han Lin Fu-Tong Liu
author_sort	Ming-Hsiang Hong
title	Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_short	Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_full	Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_fullStr	Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_full_unstemmed	Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_sort	intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
publisher	BMC
series	Journal of Biomedical Science
issn	1423-0127
publishDate	2021-03-01
description	Abstract Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate around these damaged organelles. Accumulated galectins then engage cellular proteins and subsequently control cellular responses, such as autophagy. In this review, we have summarized the stimuli that lead to the accumulation of galectins, the molecular mechanisms of galectin accumulation, and galectin-mediated cellular responses, and elaborate on the differential regulatory effects among galectins.
topic	Galectin Carbohydrates Glycans Infection Autophagy
url	https://doi.org/10.1186/s12929-021-00713-x
work_keys_str_mv	AT minghsianghong intracellulargalectinssensecytosolicallyexposedglycansasdangerandmediatecellularresponses AT ichunweng intracellulargalectinssensecytosolicallyexposedglycansasdangerandmediatecellularresponses AT fangyenli intracellulargalectinssensecytosolicallyexposedglycansasdangerandmediatecellularresponses AT weihanlin intracellulargalectinssensecytosolicallyexposedglycansasdangerandmediatecellularresponses AT futongliu intracellulargalectinssensecytosolicallyexposedglycansasdangerandmediatecellularresponses
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Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses

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