The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and Their Clinical Implications
The communication between hepatocellular carcinoma (HCC) cells and their microenvironment is an essential mechanism supporting or preventing tumor development and progression. Recent evidence has identified extracellular vesicles (EVs) as one of the mechanisms mediating paracrine signaling between c...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/12/4/823 |
id |
doaj-e781abc244d1412e9ad7c052ace07409 |
---|---|
record_format |
Article |
spelling |
doaj-e781abc244d1412e9ad7c052ace074092020-11-25T02:39:51ZengMDPI AGCancers2072-66942020-03-011282382310.3390/cancers12040823The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and Their Clinical ImplicationsDevis Pascut0Muhammad Yogi Pratama1Niem V.T. Vo2Rina Masadah3Claudio Tiribelli4Fondazione Italiana Fegato—ONLUS, Liver Research Center, Basovizza, 34149 Trieste, ItalyFondazione Italiana Fegato—ONLUS, Liver Research Center, Basovizza, 34149 Trieste, ItalyCenter for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 70000, VietnamDepartment of Pathology Anatomy, Hasanuddin University, Makassar 90245, IndonesiaFondazione Italiana Fegato—ONLUS, Liver Research Center, Basovizza, 34149 Trieste, ItalyThe communication between hepatocellular carcinoma (HCC) cells and their microenvironment is an essential mechanism supporting or preventing tumor development and progression. Recent evidence has identified extracellular vesicles (EVs) as one of the mechanisms mediating paracrine signaling between cells. Exosomes, the most described class of EVs, deliver proteins, mRNAs, noncoding RNAs, DNA, and lipids to recipient cells, also at remote distances. MicroRNAs (miRNAs), as part of the non-coding RNA exosomal cargo, have an important role in regulating cellular pathways in targeted cells, regulating several processes related to tumor progression invasion and metastasis, such as angiogenesis, immune-escape, epithelial-to-mesenchymal transition, invasion, and multi-drug resistance. Accumulating evidence suggests exosomal miRNAs as relevant players in the dynamic crosstalk among cancerous, immune, and stromal cells in establishing the tumorigenic microenvironment. In addition, they sustain the metastasic niche formation at distant sites. In this review, we summarized the recent findings on the role of the exosome-derived miRNAs in the cross-communication between tumor cells and different hepatic resident cells, with a focus on the molecular mechanisms responsible for the cell re-programming. In addition, we describe the clinical implication derived from the exosomal miRNA-driven immunomodulation to the current immunotherapy strategies and the molecular aspects influencing the resistance to therapeutic agents.https://www.mdpi.com/2072-6694/12/4/823exosomesmiRNAexosomal miRNAhepatocellular carcinomaliver cancerHCC |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Devis Pascut Muhammad Yogi Pratama Niem V.T. Vo Rina Masadah Claudio Tiribelli |
spellingShingle |
Devis Pascut Muhammad Yogi Pratama Niem V.T. Vo Rina Masadah Claudio Tiribelli The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and Their Clinical Implications Cancers exosomes miRNA exosomal miRNA hepatocellular carcinoma liver cancer HCC |
author_facet |
Devis Pascut Muhammad Yogi Pratama Niem V.T. Vo Rina Masadah Claudio Tiribelli |
author_sort |
Devis Pascut |
title |
The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and Their Clinical Implications |
title_short |
The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and Their Clinical Implications |
title_full |
The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and Their Clinical Implications |
title_fullStr |
The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and Their Clinical Implications |
title_full_unstemmed |
The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and Their Clinical Implications |
title_sort |
crosstalk between tumor cells and the microenvironment in hepatocellular carcinoma: the role of exosomal micrornas and their clinical implications |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-03-01 |
description |
The communication between hepatocellular carcinoma (HCC) cells and their microenvironment is an essential mechanism supporting or preventing tumor development and progression. Recent evidence has identified extracellular vesicles (EVs) as one of the mechanisms mediating paracrine signaling between cells. Exosomes, the most described class of EVs, deliver proteins, mRNAs, noncoding RNAs, DNA, and lipids to recipient cells, also at remote distances. MicroRNAs (miRNAs), as part of the non-coding RNA exosomal cargo, have an important role in regulating cellular pathways in targeted cells, regulating several processes related to tumor progression invasion and metastasis, such as angiogenesis, immune-escape, epithelial-to-mesenchymal transition, invasion, and multi-drug resistance. Accumulating evidence suggests exosomal miRNAs as relevant players in the dynamic crosstalk among cancerous, immune, and stromal cells in establishing the tumorigenic microenvironment. In addition, they sustain the metastasic niche formation at distant sites. In this review, we summarized the recent findings on the role of the exosome-derived miRNAs in the cross-communication between tumor cells and different hepatic resident cells, with a focus on the molecular mechanisms responsible for the cell re-programming. In addition, we describe the clinical implication derived from the exosomal miRNA-driven immunomodulation to the current immunotherapy strategies and the molecular aspects influencing the resistance to therapeutic agents. |
topic |
exosomes miRNA exosomal miRNA hepatocellular carcinoma liver cancer HCC |
url |
https://www.mdpi.com/2072-6694/12/4/823 |
work_keys_str_mv |
AT devispascut thecrosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications AT muhammadyogipratama thecrosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications AT niemvtvo thecrosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications AT rinamasadah thecrosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications AT claudiotiribelli thecrosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications AT devispascut crosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications AT muhammadyogipratama crosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications AT niemvtvo crosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications AT rinamasadah crosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications AT claudiotiribelli crosstalkbetweentumorcellsandthemicroenvironmentinhepatocellularcarcinomatheroleofexosomalmicrornasandtheirclinicalimplications |
_version_ |
1724784435999539200 |