Spectrum of Secondary Glomerular Diseases in Adult Nephrotic Syndrome
Background: In developing countries like India, the causes for end stage renal failure has been changing with glomerular diseases occupying an important place. The trend of various primary and secondary causes of Nephrotic Syndrome (NS) over the past few decades has been debatable especially wit...
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doaj-e7830bac2f2f4f8da7bb9b68805338b02020-11-25T03:55:48ZengKrishna Institute of Medical Sciences UniversityJournal of Krishna Institute of Medical Sciences University2231-42612231-42612020-07-01090319Spectrum of Secondary Glomerular Diseases in Adult Nephrotic SyndromeDevarasetty Shashank0Mohini Singh1S.R. Ramakrishnan2Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai-600116 (Tamil Nadu) IndiaDepartment of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai-600116 (Tamil Nadu) IndiaDepartment of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai-600116 (Tamil Nadu) IndiaBackground: In developing countries like India, the causes for end stage renal failure has been changing with glomerular diseases occupying an important place. The trend of various primary and secondary causes of Nephrotic Syndrome (NS) over the past few decades has been debatable especially with reference to geographical locations. Aim and Objectives: This study was intended to find out the histologic patterns of glomerular disease associated with NS in South India and analyze the corresponding clinical and biochemical abnormalities associated with these conditions. Material and Methods: One hundred eighty eight patients in the age group of 18-80 years with NS who underwent renal biopsy between the period from1stJanuary 2018 to 30thSeptember 2019 were included in this study. Baseline investigations and other investigations related to renal profile evaluation including complement levels and HIV antibody were done. Results: Focal Segmental Glomerulosclerosis (FSGS) accounted for the majority (25.5%) among primary glomerular diseases while among the secondary glomerular diseases Lupus Nephritis (LN) (51.19%) constituted the majority and a substantial contribution from Human Immunodeficiency Virus Associated Nephropathy (HIVAN). LN was seen only in female patients with a mean age of 33.36 ± 10.74 years. Among LN, Class III was the most predominant while Class IIIC was less frequent. C3 and C4 complement levels were less than normal in Class IV and Class variants of LN. Conclusion: This study highlights the spectrum of Lupus Nephritis and HIV associated nephropathy as a cause for adult NS in a tertiary care center in South India.https://www.jkimsu.com/jkimsu-vol9no3/JKIMSU,%20Vol.%209,%20No.%203,%20July-September%202020%20Page%201-9.pdfnephrotic syndromeprimary glomerular diseasesecondary glomerular diseaselupus nephritishiv associated nephropathy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Devarasetty Shashank Mohini Singh S.R. Ramakrishnan |
spellingShingle |
Devarasetty Shashank Mohini Singh S.R. Ramakrishnan Spectrum of Secondary Glomerular Diseases in Adult Nephrotic Syndrome Journal of Krishna Institute of Medical Sciences University nephrotic syndrome primary glomerular disease secondary glomerular disease lupus nephritis hiv associated nephropathy |
author_facet |
Devarasetty Shashank Mohini Singh S.R. Ramakrishnan |
author_sort |
Devarasetty Shashank |
title |
Spectrum of Secondary Glomerular Diseases in Adult Nephrotic Syndrome |
title_short |
Spectrum of Secondary Glomerular Diseases in Adult Nephrotic Syndrome |
title_full |
Spectrum of Secondary Glomerular Diseases in Adult Nephrotic Syndrome |
title_fullStr |
Spectrum of Secondary Glomerular Diseases in Adult Nephrotic Syndrome |
title_full_unstemmed |
Spectrum of Secondary Glomerular Diseases in Adult Nephrotic Syndrome |
title_sort |
spectrum of secondary glomerular diseases in adult nephrotic syndrome |
publisher |
Krishna Institute of Medical Sciences University |
series |
Journal of Krishna Institute of Medical Sciences University |
issn |
2231-4261 2231-4261 |
publishDate |
2020-07-01 |
description |
Background: In developing countries like India, the causes for end stage renal failure has been changing
with glomerular diseases occupying an important place.
The trend of various primary and secondary causes of
Nephrotic Syndrome (NS) over the past few decades
has been debatable especially with reference to geographical locations. Aim and Objectives: This study
was intended to find out the histologic patterns of
glomerular disease associated with NS in South India
and analyze the corresponding clinical and biochemical
abnormalities associated with these conditions.
Material and Methods: One hundred eighty eight
patients in the age group of 18-80 years with NS who
underwent renal biopsy between the period
from1stJanuary 2018 to 30thSeptember 2019 were
included in this study. Baseline investigations and other
investigations related to renal profile evaluation
including complement levels and HIV antibody were
done. Results: Focal Segmental Glomerulosclerosis
(FSGS) accounted for the majority (25.5%) among
primary glomerular diseases while among the
secondary glomerular diseases Lupus Nephritis (LN)
(51.19%) constituted the majority and a substantial
contribution from Human Immunodeficiency Virus
Associated Nephropathy (HIVAN). LN was seen only
in female patients with a mean age of 33.36 ± 10.74
years. Among LN, Class III was the most predominant
while Class IIIC was less frequent. C3 and C4
complement levels were less than normal in Class IV
and Class variants of LN. Conclusion: This study
highlights the spectrum of Lupus Nephritis and HIV
associated nephropathy as a cause for adult NS in a
tertiary care center in South India. |
topic |
nephrotic syndrome primary glomerular disease secondary glomerular disease lupus nephritis hiv associated nephropathy |
url |
https://www.jkimsu.com/jkimsu-vol9no3/JKIMSU,%20Vol.%209,%20No.%203,%20July-September%202020%20Page%201-9.pdf |
work_keys_str_mv |
AT devarasettyshashank spectrumofsecondaryglomerulardiseasesinadultnephroticsyndrome AT mohinisingh spectrumofsecondaryglomerulardiseasesinadultnephroticsyndrome AT srramakrishnan spectrumofsecondaryglomerulardiseasesinadultnephroticsyndrome |
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