µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone
This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The m...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-09-01
|
Series: | Materials |
Subjects: | |
Online Access: | http://www.mdpi.com/1996-1944/9/10/811 |
id |
doaj-e78449edccf4432a84602fe8cb5fa49a |
---|---|
record_format |
Article |
spelling |
doaj-e78449edccf4432a84602fe8cb5fa49a2020-11-24T23:01:20ZengMDPI AGMaterials1996-19442016-09-0191081110.3390/ma9100811ma9100811µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in BoneAnna Turyanskaya0Mirjam Rauwolf1Tilman A. Grünewald2Martin Meischel3Stefanie Stanzl-Tschegg4Jörg F. Löffler5Peter Wobrauschek6Annelie M. Weinberg7Helga C. Lichtenegger8Christina Streli9Atominstitut, TU Wien, Stadionallee 2, Vienna 1020, AustriaAtominstitut, TU Wien, Stadionallee 2, Vienna 1020, AustriaInstitute of Physics and Materials Science, University of Natural Resources and Life Sciences (BOKU), Peter-Jordan-Straße 82, Vienna 1190, AustriaInstitute of Physics and Materials Science, University of Natural Resources and Life Sciences (BOKU), Peter-Jordan-Straße 82, Vienna 1190, AustriaInstitute of Physics and Materials Science, University of Natural Resources and Life Sciences (BOKU), Peter-Jordan-Straße 82, Vienna 1190, AustriaLaboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, Vladimir-Prelog-Weg 4, Zurich 8093, SwitzerlandAtominstitut, TU Wien, Stadionallee 2, Vienna 1020, AustriaDepartment of Orthopaedics and Orthopaedic Surgery, Medical University Graz, Auenbruggerplatz 5, Graz 8036, AustriaInstitute of Physics and Materials Science, University of Natural Resources and Life Sciences (BOKU), Peter-Jordan-Straße 82, Vienna 1190, AustriaAtominstitut, TU Wien, Stadionallee 2, Vienna 1020, AustriaThis study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The measurements were performed on the implant-bearing thin sections of rat bone in a time series of implant degradation between one and 18 months. Micro X-ray fluorescence analysis (μXRF) with a special spectrometer meeting the requirements for the measurements of low-Z elements was used. It was found that the migration and accumulation behaviour of implant degradation products is element-specific. A sharp decrease in Mg was observed in the immediate vicinity of the interface and no specific accumulation or aggregation of Mg in the adjacent bone tissue was detected. By contrast, Y was found to migrate further into the bone over time and to remain in the tissue even after the complete degradation of the implant. Although the nature of Y accumulations must still be clarified, its potential health impact should be considered.http://www.mdpi.com/1996-1944/9/10/811elemental imagingyttriummagnesiumbiodegradable Mg implantsboneµXRF |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Turyanskaya Mirjam Rauwolf Tilman A. Grünewald Martin Meischel Stefanie Stanzl-Tschegg Jörg F. Löffler Peter Wobrauschek Annelie M. Weinberg Helga C. Lichtenegger Christina Streli |
spellingShingle |
Anna Turyanskaya Mirjam Rauwolf Tilman A. Grünewald Martin Meischel Stefanie Stanzl-Tschegg Jörg F. Löffler Peter Wobrauschek Annelie M. Weinberg Helga C. Lichtenegger Christina Streli µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone Materials elemental imaging yttrium magnesium biodegradable Mg implants bone µXRF |
author_facet |
Anna Turyanskaya Mirjam Rauwolf Tilman A. Grünewald Martin Meischel Stefanie Stanzl-Tschegg Jörg F. Löffler Peter Wobrauschek Annelie M. Weinberg Helga C. Lichtenegger Christina Streli |
author_sort |
Anna Turyanskaya |
title |
µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_short |
µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_full |
µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_fullStr |
µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_full_unstemmed |
µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_sort |
µxrf elemental mapping of bioresorbable magnesium-based implants in bone |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2016-09-01 |
description |
This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The measurements were performed on the implant-bearing thin sections of rat bone in a time series of implant degradation between one and 18 months. Micro X-ray fluorescence analysis (μXRF) with a special spectrometer meeting the requirements for the measurements of low-Z elements was used. It was found that the migration and accumulation behaviour of implant degradation products is element-specific. A sharp decrease in Mg was observed in the immediate vicinity of the interface and no specific accumulation or aggregation of Mg in the adjacent bone tissue was detected. By contrast, Y was found to migrate further into the bone over time and to remain in the tissue even after the complete degradation of the implant. Although the nature of Y accumulations must still be clarified, its potential health impact should be considered. |
topic |
elemental imaging yttrium magnesium biodegradable Mg implants bone µXRF |
url |
http://www.mdpi.com/1996-1944/9/10/811 |
work_keys_str_mv |
AT annaturyanskaya μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone AT mirjamrauwolf μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone AT tilmanagrunewald μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone AT martinmeischel μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone AT stefaniestanzltschegg μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone AT jorgfloffler μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone AT peterwobrauschek μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone AT anneliemweinberg μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone AT helgaclichtenegger μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone AT christinastreli μxrfelementalmappingofbioresorbablemagnesiumbasedimplantsinbone |
_version_ |
1725639949647085568 |