Combating Antibiotic Tolerance Through Activating Bacterial Metabolism
The emergence of antibiotic tolerance enables genetically susceptible bacteria to withstand the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence sheds light on the critical and underappreciated role of antibiotic tolerance in the disease burden of bacterial...
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Frontiers Media S.A.
2020-10-01
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doaj-e78d2efc09c740f19efa99e04b4190c42020-11-25T03:56:46ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-10-011110.3389/fmicb.2020.577564577564Combating Antibiotic Tolerance Through Activating Bacterial MetabolismYuan Liu0Yuan Liu1Yuan Liu2Yuan Liu3Kangni Yang4Haijie Zhang5Yuqian Jia6Zhiqiang Wang7Zhiqiang Wang8Zhiqiang Wang9College of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaInstitute of Comparative Medicine, Yangzhou University, Yangzhou, ChinaJiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaJoint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaJiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaJoint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, ChinaThe emergence of antibiotic tolerance enables genetically susceptible bacteria to withstand the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence sheds light on the critical and underappreciated role of antibiotic tolerance in the disease burden of bacterial infections. Considering this tense situation, new therapeutic strategies are urgently required for combating antibiotic tolerance. Herein, we provide an insightful illustration to distinguish between antibiotic resistance and tolerance, and highlight its clinical significance and complexities of drug-tolerant bacteria. Then, we discuss the close relationship between antibiotic tolerance and bacterial metabolism. As such, a bacterial metabolism-based approach was proposed to counter antibiotic tolerance. These exogenous metabolites including amino acids, tricarboxylic acid cycle (TCA cycle) metabolites, and nucleotides effectively activate bacterial metabolism and convert the tolerant cells to sensitive cells, and eventually restore antibiotic efficacy. A better understanding of molecular mechanisms of antibiotic tolerance particularly in vivo would substantially drive the development of novel strategies targeting bacterial metabolism.https://www.frontiersin.org/articles/10.3389/fmicb.2020.577564/fullantibiotic resistanceantibiotic toleranceantibiotic efficacybacteriametabolismmetabolites |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuan Liu Yuan Liu Yuan Liu Yuan Liu Kangni Yang Haijie Zhang Yuqian Jia Zhiqiang Wang Zhiqiang Wang Zhiqiang Wang |
spellingShingle |
Yuan Liu Yuan Liu Yuan Liu Yuan Liu Kangni Yang Haijie Zhang Yuqian Jia Zhiqiang Wang Zhiqiang Wang Zhiqiang Wang Combating Antibiotic Tolerance Through Activating Bacterial Metabolism Frontiers in Microbiology antibiotic resistance antibiotic tolerance antibiotic efficacy bacteria metabolism metabolites |
author_facet |
Yuan Liu Yuan Liu Yuan Liu Yuan Liu Kangni Yang Haijie Zhang Yuqian Jia Zhiqiang Wang Zhiqiang Wang Zhiqiang Wang |
author_sort |
Yuan Liu |
title |
Combating Antibiotic Tolerance Through Activating Bacterial Metabolism |
title_short |
Combating Antibiotic Tolerance Through Activating Bacterial Metabolism |
title_full |
Combating Antibiotic Tolerance Through Activating Bacterial Metabolism |
title_fullStr |
Combating Antibiotic Tolerance Through Activating Bacterial Metabolism |
title_full_unstemmed |
Combating Antibiotic Tolerance Through Activating Bacterial Metabolism |
title_sort |
combating antibiotic tolerance through activating bacterial metabolism |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2020-10-01 |
description |
The emergence of antibiotic tolerance enables genetically susceptible bacteria to withstand the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence sheds light on the critical and underappreciated role of antibiotic tolerance in the disease burden of bacterial infections. Considering this tense situation, new therapeutic strategies are urgently required for combating antibiotic tolerance. Herein, we provide an insightful illustration to distinguish between antibiotic resistance and tolerance, and highlight its clinical significance and complexities of drug-tolerant bacteria. Then, we discuss the close relationship between antibiotic tolerance and bacterial metabolism. As such, a bacterial metabolism-based approach was proposed to counter antibiotic tolerance. These exogenous metabolites including amino acids, tricarboxylic acid cycle (TCA cycle) metabolites, and nucleotides effectively activate bacterial metabolism and convert the tolerant cells to sensitive cells, and eventually restore antibiotic efficacy. A better understanding of molecular mechanisms of antibiotic tolerance particularly in vivo would substantially drive the development of novel strategies targeting bacterial metabolism. |
topic |
antibiotic resistance antibiotic tolerance antibiotic efficacy bacteria metabolism metabolites |
url |
https://www.frontiersin.org/articles/10.3389/fmicb.2020.577564/full |
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