Induction of CD44 variant 9-expressing cancer stem cells might attenuate the efficacy of chemoradioselection and Worsens the prognosis of patients with advanced head and neck cancer.

Induction of CD44 variant 9-expressing cancer stem cells might attenuate the efficacy of chemoradioselection and Worsens the prognosis of patients with advanced head and neck cancer.

At our institute, a chemoradioselection strategy has been used to select patients for organ preservation on the basis of response to an initial 30-40 Gy concurrent chemoradiotherapy (CCRT). Patients with a favorable response (i.e., chemoradioselected; CRS) have demonstrated better outcomes than thos...

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Bibliographic Details
Main Authors: Takeichiro Aso, Mioko Matsuo, Hideyuki Kiyohara, Kenichi Taguchi, Fumihide Rikimaru, Mototsugu Shimokawa, Yuichi Segawa, Yuichiro Higaki, Hirohito Umeno, Tadashi Nakashima, Muneyuki Masuda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4353624?pdf=render

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