A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in Children
The aim of this study was to describe and analyze epidemiological and clinical features of children screened for COVID-19 at Sibiu Pediatric Clinical Hospital during the first 9 months (March–November) of coronavirus disease pandemic in Romania. A total of 203 pediatric patients with a confirmed dia...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/10/16/3517 |
id |
doaj-e79e01895aa449219cd43029c199c3dc |
---|---|
record_format |
Article |
spelling |
doaj-e79e01895aa449219cd43029c199c3dc2021-08-26T13:55:09ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-01103517351710.3390/jcm10163517A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in ChildrenMaria Totan0Felicia Gabriela Gligor1Lavinia Duică2Nicolae Grigore3Sinziana Silișteanu4Ionela Maniu5Elisabeta Antonescu6Faculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, RomaniaDepartment of Health and Human Development, Stefan cel Mare University of Suceava, 13 University Str., 720229 Suceava, RomaniaResearch Team, Pediatric Clinical Hospital Sibiu, 550166 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, RomaniaThe aim of this study was to describe and analyze epidemiological and clinical features of children screened for COVID-19 at Sibiu Pediatric Clinical Hospital during the first 9 months (March–November) of coronavirus disease pandemic in Romania. A total of 203 pediatric patients with a confirmed diagnosis of COVID-19 were included in the study. The median age of the patients was 121 (IQR 18–181) months and 52.22% had mild clinical type with pneumonia, 35.47% were moderate cases, 3.94% severe cases, 0.99% critically ill cases and 7.39% were asymptomatic. The most common symptoms were fever (n = 130, 64.03%), nasal congestion (n = 138, 67.98%), cough (n = 128, 63.05%) followed by sore throat (n = 64, 31.52%), rhinorrhea (n = 63, 31.03%), fatigue (n = 57, 28.07%), headache (n = 47, 23.15%), diarrhea (n = 39, 19.21%), vomiting (n = 32, 15.76%), myalgia (n = 24, 11.82%), abdominal pain (n = 22, 10.83%). A higher proportion of infants with severe or critical disease was encountered with lymphopenia (n = 9, 90%), neutrophilia (n = 5, 50%), leukocytosis (n = 5, 50%) compared with asymptomatic infants (n = 10, 66.67%, n = 1, 6.67%, n = 3, 20%) or mild (n = 53, 50%, n = 19, 17.92%, n = 15, 14.15%) and moderate (n = 37, 51.39%, n = 9, 12.50%, n = 6, 8.33%) cases (<i>p</i> = 0.095, <i>p</i> = 0.042, <i>p</i> = 0.034). Pediatric patients generally had mild or moderate type of COVID-19, and the critically ill cases were rare. In our study, frequent symptoms were observed in both the systemic and respiratory systems, ear, nose and throat system, and less from gastrointestinal system, central nervous system or ocular system. Additionally, there is an increase in liver and myocardial enzyme levels with an increase in disease severity. Understanding the clinical and laboratory characteristics of pediatric patients is important for diagnosis, management and effective control of the disease.https://www.mdpi.com/2077-0383/10/16/3517coronavirusCOVID-19SARS-CoV-2childrenpediatricclinical features |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Totan Felicia Gabriela Gligor Lavinia Duică Nicolae Grigore Sinziana Silișteanu Ionela Maniu Elisabeta Antonescu |
spellingShingle |
Maria Totan Felicia Gabriela Gligor Lavinia Duică Nicolae Grigore Sinziana Silișteanu Ionela Maniu Elisabeta Antonescu A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in Children Journal of Clinical Medicine coronavirus COVID-19 SARS-CoV-2 children pediatric clinical features |
author_facet |
Maria Totan Felicia Gabriela Gligor Lavinia Duică Nicolae Grigore Sinziana Silișteanu Ionela Maniu Elisabeta Antonescu |
author_sort |
Maria Totan |
title |
A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in Children |
title_short |
A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in Children |
title_full |
A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in Children |
title_fullStr |
A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in Children |
title_full_unstemmed |
A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in Children |
title_sort |
single-center (sibiu, romania), retrospective study (march–november 2020) of covid-19 clinical and epidemiological features in children |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-08-01 |
description |
The aim of this study was to describe and analyze epidemiological and clinical features of children screened for COVID-19 at Sibiu Pediatric Clinical Hospital during the first 9 months (March–November) of coronavirus disease pandemic in Romania. A total of 203 pediatric patients with a confirmed diagnosis of COVID-19 were included in the study. The median age of the patients was 121 (IQR 18–181) months and 52.22% had mild clinical type with pneumonia, 35.47% were moderate cases, 3.94% severe cases, 0.99% critically ill cases and 7.39% were asymptomatic. The most common symptoms were fever (n = 130, 64.03%), nasal congestion (n = 138, 67.98%), cough (n = 128, 63.05%) followed by sore throat (n = 64, 31.52%), rhinorrhea (n = 63, 31.03%), fatigue (n = 57, 28.07%), headache (n = 47, 23.15%), diarrhea (n = 39, 19.21%), vomiting (n = 32, 15.76%), myalgia (n = 24, 11.82%), abdominal pain (n = 22, 10.83%). A higher proportion of infants with severe or critical disease was encountered with lymphopenia (n = 9, 90%), neutrophilia (n = 5, 50%), leukocytosis (n = 5, 50%) compared with asymptomatic infants (n = 10, 66.67%, n = 1, 6.67%, n = 3, 20%) or mild (n = 53, 50%, n = 19, 17.92%, n = 15, 14.15%) and moderate (n = 37, 51.39%, n = 9, 12.50%, n = 6, 8.33%) cases (<i>p</i> = 0.095, <i>p</i> = 0.042, <i>p</i> = 0.034). Pediatric patients generally had mild or moderate type of COVID-19, and the critically ill cases were rare. In our study, frequent symptoms were observed in both the systemic and respiratory systems, ear, nose and throat system, and less from gastrointestinal system, central nervous system or ocular system. Additionally, there is an increase in liver and myocardial enzyme levels with an increase in disease severity. Understanding the clinical and laboratory characteristics of pediatric patients is important for diagnosis, management and effective control of the disease. |
topic |
coronavirus COVID-19 SARS-CoV-2 children pediatric clinical features |
url |
https://www.mdpi.com/2077-0383/10/16/3517 |
work_keys_str_mv |
AT mariatotan asinglecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT feliciagabrielagligor asinglecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT laviniaduica asinglecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT nicolaegrigore asinglecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT sinzianasilisteanu asinglecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT ionelamaniu asinglecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT elisabetaantonescu asinglecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT mariatotan singlecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT feliciagabrielagligor singlecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT laviniaduica singlecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT nicolaegrigore singlecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT sinzianasilisteanu singlecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT ionelamaniu singlecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren AT elisabetaantonescu singlecentersibiuromaniaretrospectivestudymarchnovember2020ofcovid19clinicalandepidemiologicalfeaturesinchildren |
_version_ |
1721192430214053888 |