Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma.
<h4>Purpose</h4>To segment the inner macular layers (IML) and compare the discriminating abilities of the macular and peripapillary retinal nerve fiber layer (mRNFL and pRNFL, respectively) thicknesses in patients with early-stage normal tension glaucoma (NTG).<h4>Design</h4>...
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doaj-e7ab15bc435b41378ccf5559da8fe8ce2021-03-04T10:38:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01141e021021510.1371/journal.pone.0210215Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma.Jih-Pin LinPei-Wen LinIng-Chou LaiJen-Chia Tsai<h4>Purpose</h4>To segment the inner macular layers (IML) and compare the discriminating abilities of the macular and peripapillary retinal nerve fiber layer (mRNFL and pRNFL, respectively) thicknesses in patients with early-stage normal tension glaucoma (NTG).<h4>Design</h4>Cross-sectional study.<h4>Methods</h4>Forty-nine normal subjects and 69 preperimetric glaucoma (PPG) and 60 NTG patients were enrolled. Spectral-domain optical coherence tomography (SD-OCT) was used to obtain pRNFL and macular thickness parameters and segment the IML in all subjects. Area under the receiver operating characteristic (AUROC) curves were used to compare the diagnostic capabilities of different parameters.<h4>Results</h4>The pRNFL, total macular layer (TML), mRNFL, and macular ganglion cell layer (mGCL) were significantly thinner in the NTG group than in the PPG and normal groups. The global and superotemporal pRNFL and the mGCL in the superior outer area were the three best parameters for detecting early NTG. The discriminating capabilities of the superior and inferior mGCL were comparable to those of the corresponding pRNFL (p = 0.573, 0.841). Concerning location, the mGCL had higher AUROCs in the outer sectors (0.863, 0.837) than in the inner sectors (0.747, 0.747). Pearson's correlation coefficients also revealed significant correlations between the mGCL and pRNFL (superior: r = 0.499, inferior: r = 0.624). The strongest correlation was between the mGCL and mean deviation (MD) (superior: r = 0.434 and inferior: r = 0.402).<h4>Conclusions</h4>The diagnostic value of mGCL thickness is comparable to that of pRNFL thickness. IMLs in the outer sectors had better diagnostic capabilities than those in the inner sector for detecting early NTG.https://doi.org/10.1371/journal.pone.0210215 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jih-Pin Lin Pei-Wen Lin Ing-Chou Lai Jen-Chia Tsai |
spellingShingle |
Jih-Pin Lin Pei-Wen Lin Ing-Chou Lai Jen-Chia Tsai Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma. PLoS ONE |
author_facet |
Jih-Pin Lin Pei-Wen Lin Ing-Chou Lai Jen-Chia Tsai |
author_sort |
Jih-Pin Lin |
title |
Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma. |
title_short |
Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma. |
title_full |
Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma. |
title_fullStr |
Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma. |
title_full_unstemmed |
Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma. |
title_sort |
segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2019-01-01 |
description |
<h4>Purpose</h4>To segment the inner macular layers (IML) and compare the discriminating abilities of the macular and peripapillary retinal nerve fiber layer (mRNFL and pRNFL, respectively) thicknesses in patients with early-stage normal tension glaucoma (NTG).<h4>Design</h4>Cross-sectional study.<h4>Methods</h4>Forty-nine normal subjects and 69 preperimetric glaucoma (PPG) and 60 NTG patients were enrolled. Spectral-domain optical coherence tomography (SD-OCT) was used to obtain pRNFL and macular thickness parameters and segment the IML in all subjects. Area under the receiver operating characteristic (AUROC) curves were used to compare the diagnostic capabilities of different parameters.<h4>Results</h4>The pRNFL, total macular layer (TML), mRNFL, and macular ganglion cell layer (mGCL) were significantly thinner in the NTG group than in the PPG and normal groups. The global and superotemporal pRNFL and the mGCL in the superior outer area were the three best parameters for detecting early NTG. The discriminating capabilities of the superior and inferior mGCL were comparable to those of the corresponding pRNFL (p = 0.573, 0.841). Concerning location, the mGCL had higher AUROCs in the outer sectors (0.863, 0.837) than in the inner sectors (0.747, 0.747). Pearson's correlation coefficients also revealed significant correlations between the mGCL and pRNFL (superior: r = 0.499, inferior: r = 0.624). The strongest correlation was between the mGCL and mean deviation (MD) (superior: r = 0.434 and inferior: r = 0.402).<h4>Conclusions</h4>The diagnostic value of mGCL thickness is comparable to that of pRNFL thickness. IMLs in the outer sectors had better diagnostic capabilities than those in the inner sector for detecting early NTG. |
url |
https://doi.org/10.1371/journal.pone.0210215 |
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