Production of cloned pigs with targeted attenuation of gene expression.

Production of cloned pigs with targeted attenuation of gene expression.

The objective of this study was to demonstrate that RNA interference (RNAi) and somatic cell nuclear transfer (SCNT) technologies can be used to attenuate the expression of specific genes in tissues of swine, a large animal species. Apolipoprotein E (apoE), a secreted glycoprotein known for its majo...

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Bibliographic Details
Main Authors: Vilceu Bordignon, Nayla El-Beirouthi, Bernardo G Gasperin, Marcelo S Albornoz, Mario A Martinez-Diaz, Carine Schneider, Denyse Laurin, David Zadworny, Luis B Agellon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3667777?pdf=render

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