Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With Electroencephalogram
Background: In this report, a study protocol for a randomized control trial is presented in an attempt to explore the efficacy of mindfulness-based cognitive therapy (MBCT) for major depressive disorder (MMD), and a case–control study is conducted to find the difference in electroencephalograms (EEG...
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2021-07-01
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doaj-e7ba79fc1a174a638c9a8048663e36f52021-07-26T05:43:50ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-07-011210.3389/fpsyt.2021.499633499633Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With ElectroencephalogramTianran ZhangLanlan WangYanle BaiWenqing ZhaoYanru WuWenhui JiangQing FanJianyin QiuBackground: In this report, a study protocol for a randomized control trial is presented in an attempt to explore the efficacy of mindfulness-based cognitive therapy (MBCT) for major depressive disorder (MMD), and a case–control study is conducted to find the difference in electroencephalograms (EEGs) between MMD and normal controls.Design: Seventy Chinese patients with MMD will be chosen for random division in the MBCT group or medication group, with half of the participants receiving common medication treatment [selective serotonin reuptake inhibitors (SSRIs)] and half receiving MBCT as a supplement to the common medication treatment. All participants, namely, 70 MMD cases and 35 matched normal controls, will be tested by a range of scales and EEG at baseline (week 0), mid-intervention (weeks 2, 4, and 6), post-intervention (week 8), and 6-months follow-up (weeks 12, 20, and 32).Discussion: The findings of this study will provide a positive reference for the treatment of depression and future research on MBCT treatment mechanism.Trial Registration: NCT03558256. Registered: June 13, 2018—retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03558256.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.499633/fullmajor depressive disordermindfulness based cognitive therapyrandomized-control trialcase-control studyelectroencephalogram |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tianran Zhang Lanlan Wang Yanle Bai Wenqing Zhao Yanru Wu Wenhui Jiang Qing Fan Jianyin Qiu |
spellingShingle |
Tianran Zhang Lanlan Wang Yanle Bai Wenqing Zhao Yanru Wu Wenhui Jiang Qing Fan Jianyin Qiu Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With Electroencephalogram Frontiers in Psychiatry major depressive disorder mindfulness based cognitive therapy randomized-control trial case-control study electroencephalogram |
author_facet |
Tianran Zhang Lanlan Wang Yanle Bai Wenqing Zhao Yanru Wu Wenhui Jiang Qing Fan Jianyin Qiu |
author_sort |
Tianran Zhang |
title |
Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With Electroencephalogram |
title_short |
Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With Electroencephalogram |
title_full |
Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With Electroencephalogram |
title_fullStr |
Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With Electroencephalogram |
title_full_unstemmed |
Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With Electroencephalogram |
title_sort |
mindfulness-based cognitive therapy in major depressive disorder: a study protocol of a randomized control trial and a case–control study with electroencephalogram |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2021-07-01 |
description |
Background: In this report, a study protocol for a randomized control trial is presented in an attempt to explore the efficacy of mindfulness-based cognitive therapy (MBCT) for major depressive disorder (MMD), and a case–control study is conducted to find the difference in electroencephalograms (EEGs) between MMD and normal controls.Design: Seventy Chinese patients with MMD will be chosen for random division in the MBCT group or medication group, with half of the participants receiving common medication treatment [selective serotonin reuptake inhibitors (SSRIs)] and half receiving MBCT as a supplement to the common medication treatment. All participants, namely, 70 MMD cases and 35 matched normal controls, will be tested by a range of scales and EEG at baseline (week 0), mid-intervention (weeks 2, 4, and 6), post-intervention (week 8), and 6-months follow-up (weeks 12, 20, and 32).Discussion: The findings of this study will provide a positive reference for the treatment of depression and future research on MBCT treatment mechanism.Trial Registration: NCT03558256. Registered: June 13, 2018—retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03558256. |
topic |
major depressive disorder mindfulness based cognitive therapy randomized-control trial case-control study electroencephalogram |
url |
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.499633/full |
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