Clinical Observation of Olanzapine in Treatment of Nausea and Vomiting Caused by Opioid Analgesics
Objective To observe the efficacy and side effects of olanzapine in the treatment of nausea and vomiting caused by opioid analgesics in cancer patients. Methods We randomly divided 85 cancer patients with nausea and vomiting caused by opioid analgesics into two groups. Treatment group was treated wi...
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2018-05-01
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doaj-e7cc3f932e6d4dafbeb739e409fb03ee2020-11-25T03:26:44ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782018-05-0145532632810.3971/j.issn.1000-8578.2018.17.12758578.2018.17.1275Clinical Observation of Olanzapine in Treatment of Nausea and Vomiting Caused by Opioid AnalgesicsLI Daojun0XU Xinhua1ZHANG Jianyu2LI Cong3The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, ChinaThe First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, ChinaThe First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, ChinaChina Three Gorges University Oncology Institute, Yichang 443003, ChinaObjective To observe the efficacy and side effects of olanzapine in the treatment of nausea and vomiting caused by opioid analgesics in cancer patients. Methods We randomly divided 85 cancer patients with nausea and vomiting caused by opioid analgesics into two groups. Treatment group was treated with olanzapine tablets and control group received metoclopramide injection solution. The clinical effect and medical side effects were compared between two groups. Results Compared with control group, the treatment group was significantly better in inhibiting nausea, vomiting and reducing opioid discontinuation rate (P < 0.05). Two groups were similar in drowsiness, dizziness, edema and other adverse reactions rate (P > 0.05). The control group showed significantly higher possibility in extrapyramidal reaction (akathisia) than the treatment group (P=0.024), while only one case of tumble happened in treatment group. Conclusion Olanzapine is a good choice in the treatment of nausea and vomiting caused by opioid analgesics and worth extending its clinical application.http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1275.htmopioid analgesicsnausea and vomitingolanzapine |
collection |
DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
LI Daojun XU Xinhua ZHANG Jianyu LI Cong |
spellingShingle |
LI Daojun XU Xinhua ZHANG Jianyu LI Cong Clinical Observation of Olanzapine in Treatment of Nausea and Vomiting Caused by Opioid Analgesics Zhongliu Fangzhi Yanjiu opioid analgesics nausea and vomiting olanzapine |
author_facet |
LI Daojun XU Xinhua ZHANG Jianyu LI Cong |
author_sort |
LI Daojun |
title |
Clinical Observation of Olanzapine in Treatment of Nausea and Vomiting Caused by Opioid Analgesics |
title_short |
Clinical Observation of Olanzapine in Treatment of Nausea and Vomiting Caused by Opioid Analgesics |
title_full |
Clinical Observation of Olanzapine in Treatment of Nausea and Vomiting Caused by Opioid Analgesics |
title_fullStr |
Clinical Observation of Olanzapine in Treatment of Nausea and Vomiting Caused by Opioid Analgesics |
title_full_unstemmed |
Clinical Observation of Olanzapine in Treatment of Nausea and Vomiting Caused by Opioid Analgesics |
title_sort |
clinical observation of olanzapine in treatment of nausea and vomiting caused by opioid analgesics |
publisher |
Magazine House of Cancer Research on Prevention and Treatment |
series |
Zhongliu Fangzhi Yanjiu |
issn |
1000-8578 1000-8578 |
publishDate |
2018-05-01 |
description |
Objective To observe the efficacy and side effects of olanzapine in the treatment of nausea and vomiting caused by opioid analgesics in cancer patients. Methods We randomly divided 85 cancer patients with nausea and vomiting caused by opioid analgesics into two groups. Treatment group was treated with olanzapine tablets and control group received metoclopramide injection solution. The clinical effect and medical side effects were compared between two groups. Results Compared with control group, the treatment group was significantly better in inhibiting nausea, vomiting and reducing opioid discontinuation rate (P < 0.05). Two groups were similar in drowsiness, dizziness, edema and other adverse reactions rate (P > 0.05). The control group showed significantly higher possibility in extrapyramidal reaction (akathisia) than the treatment group (P=0.024), while only one case of tumble happened in treatment group. Conclusion Olanzapine is a good choice in the treatment of nausea and vomiting caused by opioid analgesics and worth extending its clinical application. |
topic |
opioid analgesics nausea and vomiting olanzapine |
url |
http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1275.htm |
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