An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells [version 1; referees: 2 approved]

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells [version 1; referees: 2 approved]

After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molecule inhibition of PARG has been a goal for many ye...

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Bibliographic Details
Main Authors: Dominic I. James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A. Griffiths, Nicola Hamilton, Paul Kelly, Mark O'Connor, Kerry Shea, Ian D. Waddell, Donald J. Ogilvie
Format: Article
Language:English
Published: F1000 Research Ltd 2016-04-01
Series:F1000Research
Subjects:
Cell Signaling
Medical Genetics
Structure: Replication & Repair
Online Access:http://f1000research.com/articles/5-736/v1

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