Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown how oncohistone type affects gliomagenesis. We show...

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Bibliographic Details
Main Authors: Jay F Sarthy, Michael P Meers, Derek H Janssens, Jorja G Henikoff, Heather Feldman, Patrick J Paddison, Christina M Lockwood, Nicholas A Vitanza, James M Olson, Kami Ahmad, Steven Henikoff
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
diffuse midline glioma
pediatric cancer
histone variants
replication-coupled histone deposition
Online Access:https://elifesciences.org/articles/61090

Internet

https://elifesciences.org/articles/61090

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