Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update

Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update

Sperm-specific phospholipase C zeta (PLCζ) is widely considered to be the physiological stimulus responsible for generating calcium (Ca2+) oscillations that induce egg activation and early embryonic development during mammalian fertilization. In the mammalian testis, PLCζ expression is detected at s...

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Bibliographic Details
Main Authors: Alaaeldin Saleh, Junaid Kashir, Angelos Thanassoulas, Bared Safieh-Garabedian, F. Anthony Lai, Michail Nomikos
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
sperm
phospholipase C zeta
PLC zeta
egg activation
fertilization
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00028/full

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