Maternal obesity and the development of skeletal muscle in offspring – fetal origin of metabolic disorders
Immune contact dermatitis is an inflammation of the skin resulting from exposure to allergens in the environment. The aim of this study was to compare the actions of lactoferrin (LF), a natural immunomodulator, on the elicitation phases of the cellular and humoral, cutaneous immune responses to oxaz...
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doaj-e7e624aa9c4b4d699953990214235e432020-11-24T22:15:27ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932012-01-016611010.5604/973505973505Maternal obesity and the development of skeletal muscle in offspring – fetal origin of metabolic disordersKamil Grabiec0Marta Milewska1Katarzyna Grzelkowska-Kowalczyk2Katedra Nauk Fizjologicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w WarszawieKatedra Nauk Fizjologicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w WarszawieKatedra Nauk Fizjologicznych, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w WarszawieImmune contact dermatitis is an inflammation of the skin resulting from exposure to allergens in the environment. The aim of this study was to compare the actions of lactoferrin (LF), a natural immunomodulator, on the elicitation phases of the cellular and humoral, cutaneous immune responses to oxazolone and toluene diisocyanate (TDI), respectively. LF was given i.v. in a 10 mg/mouse dose, together with the eliciting doses of the antigens. The ear edema and the number of lymphocytes in the draining lymph nodes were measured. In addition, the production of IL-2 in the cultures of lymph node cells and the content of IL-4 in lymph node cells were determined. LF had a profound inhibitory effect on the eliciting phase of the immune response to oxazolone as measured by the ear edema and lymph node cell number. The suppressive effect of LF on the effector phase of the immune response to TDI was moderate. LF had some stimulatory effect on the ex vivo content of IL-4 in lymphocytes in the immune response to TDI. On the other hand, it significantly inhibited IL-2 in vitro production in the immune response to oxazolone. The data strongly suggest that LF exerted differential actions on the activities of antigen-specific Th1 and Th2 cells involved in respective types of the cutaneous immune responses.http://journals.indexcopernicus.com/fulltxt.php?ICID=973505jądrowy czynnik NF-κBmatczyna otyłośćmięśnie szkieletowemiogeneza płodowaścieżka sygnałowa AMPKtypy włókien mięśniowychwielonienasycone kwasy tłuszczoweWnt/β-katenina |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kamil Grabiec Marta Milewska Katarzyna Grzelkowska-Kowalczyk |
spellingShingle |
Kamil Grabiec Marta Milewska Katarzyna Grzelkowska-Kowalczyk Maternal obesity and the development of skeletal muscle in offspring – fetal origin of metabolic disorders Postępy Higieny i Medycyny Doświadczalnej jądrowy czynnik NF-κB matczyna otyłość mięśnie szkieletowe miogeneza płodowa ścieżka sygnałowa AMPK typy włókien mięśniowych wielonienasycone kwasy tłuszczowe Wnt/β-katenina |
author_facet |
Kamil Grabiec Marta Milewska Katarzyna Grzelkowska-Kowalczyk |
author_sort |
Kamil Grabiec |
title |
Maternal obesity and the development of skeletal muscle in offspring – fetal origin of metabolic disorders |
title_short |
Maternal obesity and the development of skeletal muscle in offspring – fetal origin of metabolic disorders |
title_full |
Maternal obesity and the development of skeletal muscle in offspring – fetal origin of metabolic disorders |
title_fullStr |
Maternal obesity and the development of skeletal muscle in offspring – fetal origin of metabolic disorders |
title_full_unstemmed |
Maternal obesity and the development of skeletal muscle in offspring – fetal origin of metabolic disorders |
title_sort |
maternal obesity and the development of skeletal muscle in offspring – fetal origin of metabolic disorders |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2012-01-01 |
description |
Immune contact dermatitis is an inflammation of the skin resulting from exposure to allergens in the environment. The aim of this study was to compare the actions of lactoferrin (LF), a natural immunomodulator, on the elicitation phases of the cellular and humoral, cutaneous immune responses to oxazolone and toluene diisocyanate (TDI), respectively. LF was given i.v. in a 10 mg/mouse dose, together with the eliciting doses of the antigens. The ear edema and the number of lymphocytes in the draining lymph nodes were measured. In addition, the production of IL-2 in the cultures of lymph node cells and the content of IL-4 in lymph node cells were determined. LF had a profound inhibitory effect on the eliciting phase of the immune response to oxazolone as measured by the ear edema and lymph node cell number. The suppressive effect of LF on the effector phase of the immune response to TDI was moderate. LF had some stimulatory effect on the ex vivo content of IL-4 in lymphocytes in the immune response to TDI. On the other hand, it significantly inhibited IL-2 in vitro production in the immune response to oxazolone. The data strongly suggest that LF exerted differential actions on the activities of antigen-specific Th1 and Th2 cells involved in respective types of the cutaneous immune responses. |
topic |
jądrowy czynnik NF-κB matczyna otyłość mięśnie szkieletowe miogeneza płodowa ścieżka sygnałowa AMPK typy włókien mięśniowych wielonienasycone kwasy tłuszczowe Wnt/β-katenina |
url |
http://journals.indexcopernicus.com/fulltxt.php?ICID=973505 |
work_keys_str_mv |
AT kamilgrabiec maternalobesityandthedevelopmentofskeletalmuscleinoffspringfetaloriginofmetabolicdisorders AT martamilewska maternalobesityandthedevelopmentofskeletalmuscleinoffspringfetaloriginofmetabolicdisorders AT katarzynagrzelkowskakowalczyk maternalobesityandthedevelopmentofskeletalmuscleinoffspringfetaloriginofmetabolicdisorders |
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1725794264752848896 |