Maternal exposure to ambient air pollution and congenital heart defects in China
Background: Evidence of maternal exposure to ambient air pollution on congenital heart defects (CHD) has been mixed and are still relatively limited in developing countries. We aimed to investigate the association between maternal exposure to air pollution and CHD in China. Method: This longitudinal...
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Elsevier
2021-08-01
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Series: | Environment International |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021001732 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bo-Yi Yang Yanji Qu Yuming Guo Iana Markevych Joachim Heinrich Michael S. Bloom Zhipeng Bai Luke C. Knibbs Shanshan Li Gongbo Chen Bin Jalaludin Lidia Morawska Meng Gao Bin Han Yunjiang Yu Xiao-Xuan Liu Yanqiu Ou Jinzhuang Mai Xiangmin Gao Yong Wu Zhiqiang Nie Xiao-Wen Zeng Li-Wen Hu Xubo Shen Yuanzhong Zhou Shao Lin Xiaoqing Liu Guang-Hui Dong |
spellingShingle |
Bo-Yi Yang Yanji Qu Yuming Guo Iana Markevych Joachim Heinrich Michael S. Bloom Zhipeng Bai Luke C. Knibbs Shanshan Li Gongbo Chen Bin Jalaludin Lidia Morawska Meng Gao Bin Han Yunjiang Yu Xiao-Xuan Liu Yanqiu Ou Jinzhuang Mai Xiangmin Gao Yong Wu Zhiqiang Nie Xiao-Wen Zeng Li-Wen Hu Xubo Shen Yuanzhong Zhou Shao Lin Xiaoqing Liu Guang-Hui Dong Maternal exposure to ambient air pollution and congenital heart defects in China Environment International Particulate matter PM1 NO2 Congenital heart defects Case-control study |
author_facet |
Bo-Yi Yang Yanji Qu Yuming Guo Iana Markevych Joachim Heinrich Michael S. Bloom Zhipeng Bai Luke C. Knibbs Shanshan Li Gongbo Chen Bin Jalaludin Lidia Morawska Meng Gao Bin Han Yunjiang Yu Xiao-Xuan Liu Yanqiu Ou Jinzhuang Mai Xiangmin Gao Yong Wu Zhiqiang Nie Xiao-Wen Zeng Li-Wen Hu Xubo Shen Yuanzhong Zhou Shao Lin Xiaoqing Liu Guang-Hui Dong |
author_sort |
Bo-Yi Yang |
title |
Maternal exposure to ambient air pollution and congenital heart defects in China |
title_short |
Maternal exposure to ambient air pollution and congenital heart defects in China |
title_full |
Maternal exposure to ambient air pollution and congenital heart defects in China |
title_fullStr |
Maternal exposure to ambient air pollution and congenital heart defects in China |
title_full_unstemmed |
Maternal exposure to ambient air pollution and congenital heart defects in China |
title_sort |
maternal exposure to ambient air pollution and congenital heart defects in china |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2021-08-01 |
description |
Background: Evidence of maternal exposure to ambient air pollution on congenital heart defects (CHD) has been mixed and are still relatively limited in developing countries. We aimed to investigate the association between maternal exposure to air pollution and CHD in China. Method: This longitudinal, population-based, case-control study consecutively recruited fetuses with CHD and healthy volunteers from 21 cities, Southern China, between January 2006 and December 2016. Residential address at delivery was linked to random forests models to estimate maternal exposure to particulate matter with an aerodynamic diameter of ≤ 1 µm (PM1), ≤2.5 µm, and ≤10 µm as well as nitrogen dioxides, in three trimesters. The CHD cases were evaluated by obstetrician, pediatrician, or cardiologist, and confirmed by cardia ultrasound. The CHD subtypes were coded using the International Classification Diseases. Adjusted logistic regression models were used to assess the associations between air pollutants and CHD and its subtypes. Results: A total of 7055 isolated CHD and 6423 controls were included in the current analysis. Maternal air pollution exposures were consistently higher among cases than those among controls. Logistic regression analyses showed that maternal exposure to all air pollutants during the first trimester was associated with an increased odds of CHD (e.g., an interquartile range [13.3 µg/m3] increase in PM1 was associated with 1.09-fold ([95% confidence interval, 1.01–1.18]) greater odds of CHD). No significant associations were observed for maternal air pollution exposures during the second trimester and the third trimester. The pattern of the associations between air pollutants and different CHD subtypes was mixed. Conclusions: Maternal exposure to greater levels of air pollutants during the pregnancy, especially the first trimester, is associated with higher odds of CHD in offspring. Further longitudinal well-designed studies are warranted to confirm our findings. |
topic |
Particulate matter PM1 NO2 Congenital heart defects Case-control study |
url |
http://www.sciencedirect.com/science/article/pii/S0160412021001732 |
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doaj-e7f5222920ff448a844da4f50f3ebca42021-05-22T04:35:22ZengElsevierEnvironment International0160-41202021-08-01153106548Maternal exposure to ambient air pollution and congenital heart defects in ChinaBo-Yi Yang0Yanji Qu1Yuming Guo2Iana Markevych3Joachim Heinrich4Michael S. Bloom5Zhipeng Bai6Luke C. Knibbs7Shanshan Li8Gongbo Chen9Bin Jalaludin10Lidia Morawska11Meng Gao12Bin Han13Yunjiang Yu14Xiao-Xuan Liu15Yanqiu Ou16Jinzhuang Mai17Xiangmin Gao18Yong Wu19Zhiqiang Nie20Xiao-Wen Zeng21Li-Wen Hu22Xubo Shen23Yuanzhong Zhou24Shao Lin25Xiaoqing Liu26Guang-Hui Dong27Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, ChinaDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, AustraliaInstitute of Psychology, Jagiellonian University, PolandInstitute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Ziemssenstraße 1, 80336 Munich, Germany; Comprehensive Pneumology Center Munich, German Center for Lung Research, Ziemssenstraße 1, 80336 Munich, GermanyDepartments of Environmental Health Sciences and Epidemiology and Biostatics, University at Albany, State University of New York, Rensselaer, NY 12144, USAState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, ChinaSchool of Public Health, The University of Queensland, Herston, Queensland 4006, AustraliaDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, AustraliaGuangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaCentre for Air Quality and Health Research and Evaluation, Glebe, NSW 2037, Australia; Population Health, South Western Sydney Local Health District, Liverpool, NSW 2170, Australia; Ingham Institute for Applied Medical Research, Liverpool, NSW 2170, Australia; School of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, AustraliaInternational Laboratory for Air Quality and Health, Queensland University of Technology (QUT), GPO Box 2434, Brisbane, Queensland 4001, AustraliaDepartment of Geography, Hong Kong Baptist University, Hong Kong Special Administrative RegionState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, ChinaState Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, ChinaDepartment of Epidemiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, ChinaDepartment of Epidemiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, ChinaDepartment of Epidemiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, ChinaDepartment of Epidemiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563060, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563060, ChinaDepartments of Environmental Health Sciences and Epidemiology and Biostatics, University at Albany, State University of New York, Rensselaer, NY 12144, USA; Corresponding authors.at: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China (Guang-Hui Dong). Department of Epidemiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences (Xiaoqing Liu). Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Albany, New York 12144-3445, USA (Shao Lin).Department of Epidemiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, China; Corresponding authors.at: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China (Guang-Hui Dong). Department of Epidemiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences (Xiaoqing Liu). Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Albany, New York 12144-3445, USA (Shao Lin).Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; Corresponding authors.at: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China (Guang-Hui Dong). Department of Epidemiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences (Xiaoqing Liu). Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Albany, New York 12144-3445, USA (Shao Lin).Background: Evidence of maternal exposure to ambient air pollution on congenital heart defects (CHD) has been mixed and are still relatively limited in developing countries. We aimed to investigate the association between maternal exposure to air pollution and CHD in China. Method: This longitudinal, population-based, case-control study consecutively recruited fetuses with CHD and healthy volunteers from 21 cities, Southern China, between January 2006 and December 2016. Residential address at delivery was linked to random forests models to estimate maternal exposure to particulate matter with an aerodynamic diameter of ≤ 1 µm (PM1), ≤2.5 µm, and ≤10 µm as well as nitrogen dioxides, in three trimesters. The CHD cases were evaluated by obstetrician, pediatrician, or cardiologist, and confirmed by cardia ultrasound. The CHD subtypes were coded using the International Classification Diseases. Adjusted logistic regression models were used to assess the associations between air pollutants and CHD and its subtypes. Results: A total of 7055 isolated CHD and 6423 controls were included in the current analysis. Maternal air pollution exposures were consistently higher among cases than those among controls. Logistic regression analyses showed that maternal exposure to all air pollutants during the first trimester was associated with an increased odds of CHD (e.g., an interquartile range [13.3 µg/m3] increase in PM1 was associated with 1.09-fold ([95% confidence interval, 1.01–1.18]) greater odds of CHD). No significant associations were observed for maternal air pollution exposures during the second trimester and the third trimester. The pattern of the associations between air pollutants and different CHD subtypes was mixed. Conclusions: Maternal exposure to greater levels of air pollutants during the pregnancy, especially the first trimester, is associated with higher odds of CHD in offspring. Further longitudinal well-designed studies are warranted to confirm our findings.http://www.sciencedirect.com/science/article/pii/S0160412021001732Particulate matterPM1NO2Congenital heart defectsCase-control study |