Get to Understand More from Single-Cells: Current Studies of Microfluidic-Based Techniques for Single-Cell Analysis

This review describes the microfluidic techniques developed for the analysis of a single cell. The characteristics of microfluidic (e.g., little sample amount required, high-throughput performance) make this tool suitable to answer and to solve biological questions of interest about a single cell....

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Main Authors:	Shih-Jie Lo, Da-Jeng Yao
Format:	Article
Language:	English
Published:	MDPI AG 2015-07-01
Series:	International Journal of Molecular Sciences
Subjects:	microfluidic techniques single-cell manipulation single-cell analysis
Online Access:	http://www.mdpi.com/1422-0067/16/8/16763

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spelling	doaj-e7ff59b27bb3472b9f990957218b749e2020-11-24T21:16:06ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-07-01168167631677710.3390/ijms160816763ijms160816763Get to Understand More from Single-Cells: Current Studies of Microfluidic-Based Techniques for Single-Cell AnalysisShih-Jie Lo0Da-Jeng Yao1Institute of Nanoengineering and Microsystem, National Tsing Hua University, Hsinchu 300, TaiwanInstitute of Nanoengineering and Microsystem, National Tsing Hua University, Hsinchu 300, TaiwanThis review describes the microfluidic techniques developed for the analysis of a single cell. The characteristics of microfluidic (e.g., little sample amount required, high-throughput performance) make this tool suitable to answer and to solve biological questions of interest about a single cell. This review aims to introduce microfluidic related techniques for the isolation, trapping and manipulation of a single cell. The major approaches for detection in single-cell analysis are introduced; the applications of single-cell analysis are then summarized. The review concludes with discussions of the future directions and opportunities of microfluidic systems applied in analysis of a single cell.http://www.mdpi.com/1422-0067/16/8/16763microfluidic techniquessingle-cell manipulationsingle-cell analysis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shih-Jie Lo Da-Jeng Yao
spellingShingle	Shih-Jie Lo Da-Jeng Yao Get to Understand More from Single-Cells: Current Studies of Microfluidic-Based Techniques for Single-Cell Analysis International Journal of Molecular Sciences microfluidic techniques single-cell manipulation single-cell analysis
author_facet	Shih-Jie Lo Da-Jeng Yao
author_sort	Shih-Jie Lo
title	Get to Understand More from Single-Cells: Current Studies of Microfluidic-Based Techniques for Single-Cell Analysis
title_short	Get to Understand More from Single-Cells: Current Studies of Microfluidic-Based Techniques for Single-Cell Analysis
title_full	Get to Understand More from Single-Cells: Current Studies of Microfluidic-Based Techniques for Single-Cell Analysis
title_fullStr	Get to Understand More from Single-Cells: Current Studies of Microfluidic-Based Techniques for Single-Cell Analysis
title_full_unstemmed	Get to Understand More from Single-Cells: Current Studies of Microfluidic-Based Techniques for Single-Cell Analysis
title_sort	get to understand more from single-cells: current studies of microfluidic-based techniques for single-cell analysis
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2015-07-01
description	This review describes the microfluidic techniques developed for the analysis of a single cell. The characteristics of microfluidic (e.g., little sample amount required, high-throughput performance) make this tool suitable to answer and to solve biological questions of interest about a single cell. This review aims to introduce microfluidic related techniques for the isolation, trapping and manipulation of a single cell. The major approaches for detection in single-cell analysis are introduced; the applications of single-cell analysis are then summarized. The review concludes with discussions of the future directions and opportunities of microfluidic systems applied in analysis of a single cell.
topic	microfluidic techniques single-cell manipulation single-cell analysis
url	http://www.mdpi.com/1422-0067/16/8/16763
work_keys_str_mv	AT shihjielo gettounderstandmorefromsinglecellscurrentstudiesofmicrofluidicbasedtechniquesforsinglecellanalysis AT dajengyao gettounderstandmorefromsinglecellscurrentstudiesofmicrofluidicbasedtechniquesforsinglecellanalysis
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Get to Understand More from Single-Cells: Current Studies of Microfluidic-Based Techniques for Single-Cell Analysis

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