Genetic Variations of Gene Associated with Adverse Drug Reactions to Valproic Acid in Korean Epileptic Patients

Genetic Variations of Gene Associated with Adverse Drug Reactions to Valproic Acid in Korean Epileptic Patients

The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions (ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs, especially valproic acid (VPA). Our objective was to investigate the effect of ABCC2 pol...

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Bibliographic Details
Main Authors: Ji Hyun Yi, Yang-Je Cho, Won-Joo Kim, Min Goo Lee, Ji Hyun Lee
Format: Article
Language:English
Published: Korea Genome Organization 2013-12-01
Series:Genomics & Informatics
Subjects:
drug toxicity
epilepsy
genetic polymorphism
MRP2
valproic acid
Online Access:http://genominfo.org/upload/pdf/gni-11-254.pdf

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