In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers.
Knowledge of the mechanisms of assembly of amyloid proteins into aggregates is of central importance in building an understanding of neurodegenerative disease. Given that oligomeric intermediates formed during the aggregation reaction are believed to be the major toxic species, methods to track such...
Main Authors: | Enrico Zurlo, Pravin Kumar, Georg Meisl, Alexander J Dear, Dipro Mondal, Mireille M A E Claessens, Tuomas P J Knowles, Martina Huber |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0245548 |
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