Uncommon manifestations of a rare disease: a case of autoimmune GFAP astrocytopathy
Abstract Background Manifestations of intractable hyponatremia and hypokalemia in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy have been rarely reported. Case presentation A 75-year-old male patient presented as the case of syndrome of inappropriate antidiuretic hormone secretion...
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doaj-e807862f20f04ae4ad96f035c891ff0f2021-01-31T16:12:58ZengBMCBMC Neurology1471-23772021-01-012111510.1186/s12883-021-02070-6Uncommon manifestations of a rare disease: a case of autoimmune GFAP astrocytopathyHong Di0Yue Yin1Ruxuan Chen2Yun Zhang3Jun Ni4Xuejun Zeng5Department of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeDepartment of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeAbstract Background Manifestations of intractable hyponatremia and hypokalemia in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy have been rarely reported. Case presentation A 75-year-old male patient presented as the case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) and intractable hypokalemia, showed fever, fatigue, and mental disorders. Signs and symptoms of meningoencephalitis, ataxia, and cognitive abnormalities. Magnetic resonance imaging (MRI) revealed multiple white matter lesions of the central nervous system. He had GFAP-IgG in the cerebrospinal fluid (CSF). After treatment with corticosteroids, his symptoms were alleviated gradually, and the level of electrolytes was normal. However, head contrast-enhanced MRI + susceptibility-weighted imaging (SWI) showed a wide afflicted region, and the serum GFAP-IgG turned positive. Considering the relapse of the disease, ha was treated with immunoglobulin and mycophenolate mofetil (MMF) to stabilize his condition. Conclusion This case showed a rare disease with uncommon manifestations, suggesting that careful examination and timely diagnosis are essential for disease management and satisfactory prognosis.https://doi.org/10.1186/s12883-021-02070-6Glial fibrillary acidic protein (GFAP) astrocytopathyHyponatremiaHypokalemiaFatigue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong Di Yue Yin Ruxuan Chen Yun Zhang Jun Ni Xuejun Zeng |
spellingShingle |
Hong Di Yue Yin Ruxuan Chen Yun Zhang Jun Ni Xuejun Zeng Uncommon manifestations of a rare disease: a case of autoimmune GFAP astrocytopathy BMC Neurology Glial fibrillary acidic protein (GFAP) astrocytopathy Hyponatremia Hypokalemia Fatigue |
author_facet |
Hong Di Yue Yin Ruxuan Chen Yun Zhang Jun Ni Xuejun Zeng |
author_sort |
Hong Di |
title |
Uncommon manifestations of a rare disease: a case of autoimmune GFAP astrocytopathy |
title_short |
Uncommon manifestations of a rare disease: a case of autoimmune GFAP astrocytopathy |
title_full |
Uncommon manifestations of a rare disease: a case of autoimmune GFAP astrocytopathy |
title_fullStr |
Uncommon manifestations of a rare disease: a case of autoimmune GFAP astrocytopathy |
title_full_unstemmed |
Uncommon manifestations of a rare disease: a case of autoimmune GFAP astrocytopathy |
title_sort |
uncommon manifestations of a rare disease: a case of autoimmune gfap astrocytopathy |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2021-01-01 |
description |
Abstract Background Manifestations of intractable hyponatremia and hypokalemia in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy have been rarely reported. Case presentation A 75-year-old male patient presented as the case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) and intractable hypokalemia, showed fever, fatigue, and mental disorders. Signs and symptoms of meningoencephalitis, ataxia, and cognitive abnormalities. Magnetic resonance imaging (MRI) revealed multiple white matter lesions of the central nervous system. He had GFAP-IgG in the cerebrospinal fluid (CSF). After treatment with corticosteroids, his symptoms were alleviated gradually, and the level of electrolytes was normal. However, head contrast-enhanced MRI + susceptibility-weighted imaging (SWI) showed a wide afflicted region, and the serum GFAP-IgG turned positive. Considering the relapse of the disease, ha was treated with immunoglobulin and mycophenolate mofetil (MMF) to stabilize his condition. Conclusion This case showed a rare disease with uncommon manifestations, suggesting that careful examination and timely diagnosis are essential for disease management and satisfactory prognosis. |
topic |
Glial fibrillary acidic protein (GFAP) astrocytopathy Hyponatremia Hypokalemia Fatigue |
url |
https://doi.org/10.1186/s12883-021-02070-6 |
work_keys_str_mv |
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