How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions
Abstract. Nocebo effects, such as side effects due to negative expectations regarding the pain treatment, are a concern for health care providers and come with significant costs. This narrative review focuses on underlying mechanisms and possible factors that contribute to the susceptibility to the...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer
2019-06-01
|
Series: | PAIN Reports |
Online Access: | http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000699 |
id |
doaj-e8122d215d1e41c398265d0553413019 |
---|---|
record_format |
Article |
spelling |
doaj-e8122d215d1e41c398265d05534130192020-11-25T02:17:20ZengWolters KluwerPAIN Reports2471-25312019-06-0143e69910.1097/PR9.0000000000000699201906000-00023How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventionsMeriem Manaï0Henriët van Middendorp1Dieuwke S. Veldhuijzen2Tom W.J. Huizinga3Andrea W.M. Evers4a Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlandsa Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlandsa Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the NetherlandsDepartments of c Rheumatology anda Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the NetherlandsAbstract. Nocebo effects, such as side effects due to negative expectations regarding the pain treatment, are a concern for health care providers and come with significant costs. This narrative review focuses on underlying mechanisms and possible factors that contribute to the susceptibility to the nocebo effect on pain and related outcomes and suggests strategies that can prevent, minimize, or extinguish nocebo effects in clinical settings. Nocebo effects are the result of psychological (eg, conditioning, verbal suggestions, and observational learning) and neurobiological (eg, cholecystokinin and dopamine regulation) mechanisms. Evidence from clinical and experimental studies lead to various recommendations and strategies to alter the nocebo effect in order to optimize pain treatments, such as providing patients with enhanced information, optimizing patient–physician communication and relationships, and offering psychoeducation on coping skills in order to manage patient expectations. The current literature from both clinical and experimental studies provides a better understanding of the nocebo effect and possible factors that modulate its strength on treatment outcomes. This allows for the development of evidence-based strategies aimed at the prevention, minimization, and treatment of the nocebo effect in pain conditions and possible other somatic disorders.http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000699 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meriem Manaï Henriët van Middendorp Dieuwke S. Veldhuijzen Tom W.J. Huizinga Andrea W.M. Evers |
spellingShingle |
Meriem Manaï Henriët van Middendorp Dieuwke S. Veldhuijzen Tom W.J. Huizinga Andrea W.M. Evers How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions PAIN Reports |
author_facet |
Meriem Manaï Henriët van Middendorp Dieuwke S. Veldhuijzen Tom W.J. Huizinga Andrea W.M. Evers |
author_sort |
Meriem Manaï |
title |
How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions |
title_short |
How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions |
title_full |
How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions |
title_fullStr |
How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions |
title_full_unstemmed |
How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions |
title_sort |
how to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions |
publisher |
Wolters Kluwer |
series |
PAIN Reports |
issn |
2471-2531 |
publishDate |
2019-06-01 |
description |
Abstract. Nocebo effects, such as side effects due to negative expectations regarding the pain treatment, are a concern for health care providers and come with significant costs. This narrative review focuses on underlying mechanisms and possible factors that contribute to the susceptibility to the nocebo effect on pain and related outcomes and suggests strategies that can prevent, minimize, or extinguish nocebo effects in clinical settings. Nocebo effects are the result of psychological (eg, conditioning, verbal suggestions, and observational learning) and neurobiological (eg, cholecystokinin and dopamine regulation) mechanisms. Evidence from clinical and experimental studies lead to various recommendations and strategies to alter the nocebo effect in order to optimize pain treatments, such as providing patients with enhanced information, optimizing patient–physician communication and relationships, and offering psychoeducation on coping skills in order to manage patient expectations. The current literature from both clinical and experimental studies provides a better understanding of the nocebo effect and possible factors that modulate its strength on treatment outcomes. This allows for the development of evidence-based strategies aimed at the prevention, minimization, and treatment of the nocebo effect in pain conditions and possible other somatic disorders. |
url |
http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000699 |
work_keys_str_mv |
AT meriemmanai howtopreventminimizeorextinguishnoceboeffectsinpainanarrativereviewonmechanismspredictorsandinterventions AT henrietvanmiddendorp howtopreventminimizeorextinguishnoceboeffectsinpainanarrativereviewonmechanismspredictorsandinterventions AT dieuwkesveldhuijzen howtopreventminimizeorextinguishnoceboeffectsinpainanarrativereviewonmechanismspredictorsandinterventions AT tomwjhuizinga howtopreventminimizeorextinguishnoceboeffectsinpainanarrativereviewonmechanismspredictorsandinterventions AT andreawmevers howtopreventminimizeorextinguishnoceboeffectsinpainanarrativereviewonmechanismspredictorsandinterventions |
_version_ |
1724886905740328960 |