Pre-Operative Decitabine in Colon Cancer Patients: Analyses on WNT Target Methylation and Expression

Pre-Operative Decitabine in Colon Cancer Patients: Analyses on WNT Target Methylation and Expression

DNA hypermethylation is common in colon cancer. Previously, we have shown that methylation of WNT target genes predicts poor prognosis in stage II colon cancer. The primary objective of this study was to assess whether pre-operative treatment with decitabine can decrease methylation and increase the...

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Bibliographic Details
Main Authors: Janneke F. Linnekamp, Raju Kandimalla, Evelyn Fessler, Joan H. de Jong, Hans M. Rodermond, Gregor G. W. van Bochove, Frans O. The, Cornelis J. A. Punt, Willem A. Bemelman, Anthony W. H. van de Ven, Pieter J. Tanis, Elles M. Kemper, Lianne Koens, Evelien Dekker, Louis Vermeulen, Hanneke W. M. van Laarhoven, Jan Paul Medema
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
decitabine
colon cancer
DNA methylation
clinical translation study
Online Access:https://www.mdpi.com/2072-6694/13/10/2357

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https://www.mdpi.com/2072-6694/13/10/2357

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