Microwave-assisted one-pot syntheses of 4-aminoquinazolines

Microwave-assisted one-pot syntheses of 4-aminoquinazolines

A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives 3, 4, and 5 were confirmed by single-crystal X-ray diffraction. The in vitro cytotoxicity of each compound was investigated using an M...

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Bibliographic Details
Main Authors: Song Wenting, He Shunli, Yuan Zeli, Yu Guangqing, Wu Di, Wu Qing, Zhang Minqing, Chen Yongzheng, Hu Qinghong
Format: Article
Language:English
Published: De Gruyter 2016-06-01
Series:Green Processing and Synthesis
Subjects:
4-aminoquinazoline
methodology
microwave assisted
one-pot syntheses
Online Access:https://doi.org/10.1515/gps-2015-0121
id doaj-e81e5dda22424c279c64c89cb0585867
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spelling doaj-e81e5dda22424c279c64c89cb05858672021-10-02T19:16:24ZengDe GruyterGreen Processing and Synthesis2191-95422191-95502016-06-015324725210.1515/gps-2015-0121Microwave-assisted one-pot syntheses of 4-aminoquinazolinesSong Wenting0He Shunli1Yuan Zeli2Yu Guangqing3Wu Di4Wu Qing5Zhang Minqing6Chen Yongzheng7Hu Qinghong8School of Pharmacy, Zunyi Medical University, No. 201 Dalian Road, Huichuan, Zunyi, Guizhou, 563000, ChinaSchool of Pharmacy, Zunyi Medical University, No. 201 Dalian Road, Huichuan, Zunyi, Guizhou, 563000, ChinaSchool of Pharmacy, Zunyi Medical University, No. 201 Dalian Road, Huichuan, Zunyi, Guizhou, 563000, ChinaSchool of Pharmacy, Zunyi Medical University, No. 201 Dalian Road, Huichuan, Zunyi, Guizhou, 563000, ChinaSchool of Pharmacy, Zunyi Medical University, No. 201 Dalian Road, Huichuan, Zunyi, Guizhou, 563000, ChinaSchool of Pharmacy, Zunyi Medical University, No. 201 Dalian Road, Huichuan, Zunyi, Guizhou, 563000, ChinaSchool of Pharmacy, Zunyi Medical University, No. 201 Dalian Road, Huichuan, Zunyi, Guizhou, 563000, ChinaSchool of Pharmacy, Zunyi Medical University, No. 201 Dalian Road, Huichuan, Zunyi, Guizhou, 563000, ChinaSchool of Pharmacy, Zunyi Medical University, No. 201 Dalian Road, Huichuan, Zunyi, Guizhou, 563000, ChinaA simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives 3, 4, and 5 were confirmed by single-crystal X-ray diffraction. The in vitro cytotoxicity of each compound was investigated using an MTT assay with A549 and HepG2 cell lines to calculate half-maximal inhibitory concentrations.https://doi.org/10.1515/gps-2015-01214-aminoquinazolinemethodologymicrowave assistedone-pot syntheses
collection DOAJ
language English
format Article
sources DOAJ
author Song Wenting
He Shunli
Yuan Zeli
Yu Guangqing
Wu Di
Wu Qing
Zhang Minqing
Chen Yongzheng
Hu Qinghong
spellingShingle Song Wenting
He Shunli
Yuan Zeli
Yu Guangqing
Wu Di
Wu Qing
Zhang Minqing
Chen Yongzheng
Hu Qinghong
Microwave-assisted one-pot syntheses of 4-aminoquinazolines
Green Processing and Synthesis
4-aminoquinazoline
methodology
microwave assisted
one-pot syntheses
author_facet Song Wenting
He Shunli
Yuan Zeli
Yu Guangqing
Wu Di
Wu Qing
Zhang Minqing
Chen Yongzheng
Hu Qinghong
author_sort Song Wenting
title Microwave-assisted one-pot syntheses of 4-aminoquinazolines
title_short Microwave-assisted one-pot syntheses of 4-aminoquinazolines
title_full Microwave-assisted one-pot syntheses of 4-aminoquinazolines
title_fullStr Microwave-assisted one-pot syntheses of 4-aminoquinazolines
title_full_unstemmed Microwave-assisted one-pot syntheses of 4-aminoquinazolines
title_sort microwave-assisted one-pot syntheses of 4-aminoquinazolines
publisher De Gruyter
series Green Processing and Synthesis
issn 2191-9542
2191-9550
publishDate 2016-06-01
description A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives 3, 4, and 5 were confirmed by single-crystal X-ray diffraction. The in vitro cytotoxicity of each compound was investigated using an MTT assay with A549 and HepG2 cell lines to calculate half-maximal inhibitory concentrations.
topic 4-aminoquinazoline
methodology
microwave assisted
one-pot syntheses
url https://doi.org/10.1515/gps-2015-0121
work_keys_str_mv AT songwenting microwaveassistedonepotsynthesesof4aminoquinazolines
AT heshunli microwaveassistedonepotsynthesesof4aminoquinazolines
AT yuanzeli microwaveassistedonepotsynthesesof4aminoquinazolines
AT yuguangqing microwaveassistedonepotsynthesesof4aminoquinazolines
AT wudi microwaveassistedonepotsynthesesof4aminoquinazolines
AT wuqing microwaveassistedonepotsynthesesof4aminoquinazolines
AT zhangminqing microwaveassistedonepotsynthesesof4aminoquinazolines
AT chenyongzheng microwaveassistedonepotsynthesesof4aminoquinazolines
AT huqinghong microwaveassistedonepotsynthesesof4aminoquinazolines
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