Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study
Background: Although several studies suggest the benefit of a low-protein diet supplemented with amino acids and keto acids (sLPD) in delaying the initiation of hemodialysis, evidence on whether these nutritional approaches could delay the timing of preemptive transplantation is lacking. Methods: Re...
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doaj-e82ad45389d241bf990dbdbb55acf2c52021-09-26T00:51:17ZengMDPI AGNutrients2072-66432021-08-01133002300210.3390/nu13093002Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort StudyChieh-Li Yen0Pei-Chun Fan1George Kuo2Chao-Yu Chen3Ya-Lien Cheng4Hsiang-Hao Hsu5Ya-Chun Tian6Antoine Chatrenet7Giorgina Barbara Piccoli8Chih-Hsiang Chang9Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, TaiwanKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, TaiwanKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, TaiwanKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, TaiwanKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, TaiwanKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, TaiwanKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, TaiwanNéphrologie, Centre Hospitalier du Mans, 72037 Le Mans, FranceNéphrologie, Centre Hospitalier du Mans, 72037 Le Mans, FranceKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, TaiwanBackground: Although several studies suggest the benefit of a low-protein diet supplemented with amino acids and keto acids (sLPD) in delaying the initiation of hemodialysis, evidence on whether these nutritional approaches could delay the timing of preemptive transplantation is lacking. Methods: Retrospective nationwide cohort study, from Taiwan’s National Health Insurance Research Database. Patients having undergone a first preemptive kidney transplantation between 2001 and 2017 were identified and divided into two groups according to the presence of sLPD treatment or not. The primary outcome was the time between the diagnosis of advanced CKD and transplantation. Secondary outcomes were post-transplantation adverse events. Results: A total of 245 patients who received their first preemptive kidney transplantation were identified from the nationwide database; 63 of them had been on an sLPD prior to transplantation (sLPD group). The duration between the day of advanced CKD diagnosis and the day of transplantation was significantly longer in the sLPD group compared with the non-sLPD group (median duration: 345 vs. 220 days, <i>p</i> = 0.001). The risk of post-transplantation adverse events did not differ between the two groups. Conclusions: Within the limits of its observational, retrospective design, this is the first study to suggest that nutritional management with sLPDs can safely delay the timing of preemptive kidney transplantation.https://www.mdpi.com/2072-6643/13/9/3002chronic kidney diseaselow protein dietamino acid and keto acid supplementationpreemptive kidney transplantationadverse events |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chieh-Li Yen Pei-Chun Fan George Kuo Chao-Yu Chen Ya-Lien Cheng Hsiang-Hao Hsu Ya-Chun Tian Antoine Chatrenet Giorgina Barbara Piccoli Chih-Hsiang Chang |
spellingShingle |
Chieh-Li Yen Pei-Chun Fan George Kuo Chao-Yu Chen Ya-Lien Cheng Hsiang-Hao Hsu Ya-Chun Tian Antoine Chatrenet Giorgina Barbara Piccoli Chih-Hsiang Chang Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study Nutrients chronic kidney disease low protein diet amino acid and keto acid supplementation preemptive kidney transplantation adverse events |
author_facet |
Chieh-Li Yen Pei-Chun Fan George Kuo Chao-Yu Chen Ya-Lien Cheng Hsiang-Hao Hsu Ya-Chun Tian Antoine Chatrenet Giorgina Barbara Piccoli Chih-Hsiang Chang |
author_sort |
Chieh-Li Yen |
title |
Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study |
title_short |
Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study |
title_full |
Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study |
title_fullStr |
Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study |
title_full_unstemmed |
Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study |
title_sort |
supplemented low-protein diet may delay the need for preemptive kidney transplantation: a nationwide population-based cohort study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-08-01 |
description |
Background: Although several studies suggest the benefit of a low-protein diet supplemented with amino acids and keto acids (sLPD) in delaying the initiation of hemodialysis, evidence on whether these nutritional approaches could delay the timing of preemptive transplantation is lacking. Methods: Retrospective nationwide cohort study, from Taiwan’s National Health Insurance Research Database. Patients having undergone a first preemptive kidney transplantation between 2001 and 2017 were identified and divided into two groups according to the presence of sLPD treatment or not. The primary outcome was the time between the diagnosis of advanced CKD and transplantation. Secondary outcomes were post-transplantation adverse events. Results: A total of 245 patients who received their first preemptive kidney transplantation were identified from the nationwide database; 63 of them had been on an sLPD prior to transplantation (sLPD group). The duration between the day of advanced CKD diagnosis and the day of transplantation was significantly longer in the sLPD group compared with the non-sLPD group (median duration: 345 vs. 220 days, <i>p</i> = 0.001). The risk of post-transplantation adverse events did not differ between the two groups. Conclusions: Within the limits of its observational, retrospective design, this is the first study to suggest that nutritional management with sLPDs can safely delay the timing of preemptive kidney transplantation. |
topic |
chronic kidney disease low protein diet amino acid and keto acid supplementation preemptive kidney transplantation adverse events |
url |
https://www.mdpi.com/2072-6643/13/9/3002 |
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