Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice

Objectives. To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods. An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally aft...

Full description

Bibliographic Details
Main Authors:	Heng Yang, Wei Ni, Hanqiang Jiang, Yu Lei, Jiabin Su, Yuxiang Gu, Liangfu Zhou
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Behavioural Neurology
Online Access:	http://dx.doi.org/10.1155/2018/6583267

id	doaj-e82fe12361be4e6d848c385cc700ce4f
record_format	Article
spelling	doaj-e82fe12361be4e6d848c385cc700ce4f2021-07-02T15:08:38ZengHindawi LimitedBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/65832676583267Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in MiceHeng Yang0Wei Ni1Hanqiang Jiang2Yu Lei3Jiabin Su4Yuxiang Gu5Liangfu Zhou6Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaObjectives. To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods. An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma volume and hemoglobin level were measured to examine hematoma resolution. A behavior test and brain edema and white matter injury examinations indicated brain injury after ICH. Results. Scriptaid treatment promoted hematoma resolution and reduced the hematoma volume 7 d after ICH compared with the vehicle group (P<0.05). Scriptaid treatment also alleviated the brain water content in the ipsilateral basal ganglia (P<0.05) and cortex (P<0.01) 3 d after ICH. In addition, Scriptaid improved neurological function recovery and alleviated white matter injury 35 d after ICH. Conclusions. Scriptaid can protect against brain injury after ICH and may be considered a new medical therapy method for ICH.http://dx.doi.org/10.1155/2018/6583267
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Heng Yang Wei Ni Hanqiang Jiang Yu Lei Jiabin Su Yuxiang Gu Liangfu Zhou
spellingShingle	Heng Yang Wei Ni Hanqiang Jiang Yu Lei Jiabin Su Yuxiang Gu Liangfu Zhou Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice Behavioural Neurology
author_facet	Heng Yang Wei Ni Hanqiang Jiang Yu Lei Jiabin Su Yuxiang Gu Liangfu Zhou
author_sort	Heng Yang
title	Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice
title_short	Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice
title_full	Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice
title_fullStr	Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice
title_full_unstemmed	Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice
title_sort	histone deacetylase inhibitor scriptaid alleviated neurological dysfunction after experimental intracerebral hemorrhage in mice
publisher	Hindawi Limited
series	Behavioural Neurology
issn	0953-4180 1875-8584
publishDate	2018-01-01
description	Objectives. To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods. An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma volume and hemoglobin level were measured to examine hematoma resolution. A behavior test and brain edema and white matter injury examinations indicated brain injury after ICH. Results. Scriptaid treatment promoted hematoma resolution and reduced the hematoma volume 7 d after ICH compared with the vehicle group (P<0.05). Scriptaid treatment also alleviated the brain water content in the ipsilateral basal ganglia (P<0.05) and cortex (P<0.01) 3 d after ICH. In addition, Scriptaid improved neurological function recovery and alleviated white matter injury 35 d after ICH. Conclusions. Scriptaid can protect against brain injury after ICH and may be considered a new medical therapy method for ICH.
url	http://dx.doi.org/10.1155/2018/6583267
work_keys_str_mv	AT hengyang histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT weini histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT hanqiangjiang histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT yulei histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT jiabinsu histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT yuxianggu histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice AT liangfuzhou histonedeacetylaseinhibitorscriptaidalleviatedneurologicaldysfunctionafterexperimentalintracerebralhemorrhageinmice
_version_	1721327516475457536

Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice

Similar Items