Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia

Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia

Abstract Background Sphingosine- 1-Phosphate (S1P) is a bioactive lipid and an intracellular as well as an extracellular signaling molecule. S1P ligand specifically binds to five related cell surface G-protein-coupled receptors (S1P1-5). S1P levels are tightly regulated by its synthesis catalyzed by...

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Bibliographic Details
Main Authors: Viswanathan Natarajan, Alison W. Ha, Yangbasai Dong, Narsa M. Reddy, David L. Ebenezer, Prasad Kanteti, Sekhar P. Reddy, J. Usha Raj, Zhengdeng Lei, Mark Maienschein-Cline, Zarema Arbieva, Anantha Harijith
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Genomics
Subjects:
Sphingosine kinase 1
Sphingosine 1 phosphate
Oxidative stress
Lipid signaling
Neonatal lung injury
Online Access:http://link.springer.com/article/10.1186/s12864-017-4048-0

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