Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier
Few studies have investigated the association between genetic variation and obesity traits in Indian populations or the role of environmental factors as modifiers of these relationships. In the context of rapid urbanisation, resulting in significant lifestyle changes, understanding the aetiology of...
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2011-01-01
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Online Access: | http://dx.doi.org/10.1155/2011/307542 |
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doaj-e8354c422ead4df595bb66399f3d37002020-11-24T20:44:59ZengHindawi LimitedJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/307542307542Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect ModifierA. E. Taylor0M. N. Sandeep1C. S. Janipalli2C. Giambartolomei3D. M. Evans4M. V. Kranthi Kumar5D. G. Vinay6P. Smitha7V. Gupta8M. Aruna9S. Kinra10R. M. Sullivan11L. Bowen12N. J. Timpson13G. Davey Smith14F. Dudbridge15D. Prabhakaran16Y. Ben-Shlomo17K. S. Reddy18S. Ebrahim19G. R. Chandak20School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UKCentre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Hyderabad, IndiaCentre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Hyderabad, IndiaFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UKSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UKCentre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Hyderabad, IndiaCentre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Hyderabad, IndiaCentre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Hyderabad, IndiaSouth Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi 110 016, IndiaCentre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Hyderabad, IndiaFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UKFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UKFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UKSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UKSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UKFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UKSouth Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi 110 016, IndiaSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UKPublic Health Foundation of India, New Delhi 110 016, IndiaFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UKCentre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Hyderabad, IndiaFew studies have investigated the association between genetic variation and obesity traits in Indian populations or the role of environmental factors as modifiers of these relationships. In the context of rapid urbanisation, resulting in significant lifestyle changes, understanding the aetiology of obesity is important. We investigated associations of FTO and MC4R variants with obesity traits in 3390 sibling pairs from four Indian cities, most of whom were discordant for current dwelling (rural or urban). The FTO variant rs9939609 predicted increased weight (0.09 Z-scores, 95% CI: 0.03, 0.15) and BMI (0.08 Z-scores, 95% CI: 0.02, 0.14). The MC4R variant rs17782313 was weakly associated with weight and hip circumference (P<.05). There was some indication that the association between FTO and weight was stronger in urban than that in rural dwellers (P for interaction = .03), but no evidence for effect modification by diet or physical activity. Further studies are needed to investigate ways in which urban environment may modify genetic risk of obesity.http://dx.doi.org/10.1155/2011/307542 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A. E. Taylor M. N. Sandeep C. S. Janipalli C. Giambartolomei D. M. Evans M. V. Kranthi Kumar D. G. Vinay P. Smitha V. Gupta M. Aruna S. Kinra R. M. Sullivan L. Bowen N. J. Timpson G. Davey Smith F. Dudbridge D. Prabhakaran Y. Ben-Shlomo K. S. Reddy S. Ebrahim G. R. Chandak |
spellingShingle |
A. E. Taylor M. N. Sandeep C. S. Janipalli C. Giambartolomei D. M. Evans M. V. Kranthi Kumar D. G. Vinay P. Smitha V. Gupta M. Aruna S. Kinra R. M. Sullivan L. Bowen N. J. Timpson G. Davey Smith F. Dudbridge D. Prabhakaran Y. Ben-Shlomo K. S. Reddy S. Ebrahim G. R. Chandak Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier Journal of Obesity |
author_facet |
A. E. Taylor M. N. Sandeep C. S. Janipalli C. Giambartolomei D. M. Evans M. V. Kranthi Kumar D. G. Vinay P. Smitha V. Gupta M. Aruna S. Kinra R. M. Sullivan L. Bowen N. J. Timpson G. Davey Smith F. Dudbridge D. Prabhakaran Y. Ben-Shlomo K. S. Reddy S. Ebrahim G. R. Chandak |
author_sort |
A. E. Taylor |
title |
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier |
title_short |
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier |
title_full |
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier |
title_fullStr |
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier |
title_full_unstemmed |
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier |
title_sort |
associations of fto and mc4r variants with obesity traits in indians and the role of rural/urban environment as a possible effect modifier |
publisher |
Hindawi Limited |
series |
Journal of Obesity |
issn |
2090-0708 2090-0716 |
publishDate |
2011-01-01 |
description |
Few studies have investigated the association between genetic variation and obesity traits in Indian populations or the role of environmental factors as modifiers of these relationships. In the context of rapid urbanisation, resulting in significant lifestyle changes, understanding the aetiology of obesity is important. We investigated associations of FTO and MC4R variants with obesity traits in 3390 sibling pairs from four Indian cities, most of whom were discordant for current dwelling (rural or urban). The FTO variant rs9939609 predicted increased weight (0.09 Z-scores, 95% CI: 0.03, 0.15) and BMI (0.08 Z-scores, 95% CI: 0.02, 0.14). The MC4R variant rs17782313 was weakly associated with weight and hip circumference (P<.05). There was some indication that the association between FTO and weight was stronger in urban than that in rural dwellers (P for interaction = .03), but no evidence for effect modification by diet or physical activity. Further studies are needed to investigate ways in which urban environment may modify genetic risk of obesity. |
url |
http://dx.doi.org/10.1155/2011/307542 |
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