Supersaturated Lipid-Based Formulations to Enhance the Oral Bioavailability of Venetoclax
Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. However, many drug candidates display insufficient lipid solubility, leading t...
Main Authors: | Niklas J. Koehl, Laura J. Henze, Martin Kuentz, René Holm, Brendan T. Griffin |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/12/6/564 |
Similar Items
-
Artificial Neural Networks to Predict the Apparent Degree of Supersaturation in Supersaturated Lipid-Based Formulations: A Pilot Study
by: Harriet Bennett-Lenane, et al.
Published: (2021-09-01) -
Biorelevant test for supersaturable formulation
by: Enxian Lu, et al.
Published: (2017-01-01) -
Understanding the effect of lipid formulation loading and ethanol as a diluent on solidification of pitavastatin super-saturable SNEDDS using factorial design approach
by: Ilham Kuncahyo, et al.
Published: (2019-01-01) -
Physicochemical Understanding of Solubility and Supersaturation for the Enhancement of the Oral Absorbability of Poorly Soluble Drugs
by: Ozaki, Shunsuke
Published: (2015) -
The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers
by: Lasse I. Blaabjerg, et al.
Published: (2018-09-01)