17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway

17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway

Dysregulated glutamate signaling, leading to neuronal excitotoxicity and death, has been associated with neurodegenerative pathologies. 17β-estradiol (E2) is a human steroid hormone having a role in reproduction, sexual maturation, brain health and biological activities. The study aimed to explain t...

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Bibliographic Details
Main Authors: Ibrahim Khan, Kamran Saeed, Min Gi Jo, Myeong Ok Kim
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
17β-estradiol
glutamate
oxidative stress
MAP-kinases
neuroinflammation
gliosis
Online Access:https://www.mdpi.com/2076-3921/10/6/892

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