Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity
Background: Cichorium intybus L. commonly known as chicory is one of the important medicinal plants commonly used in Ayurvedic system of medicine. It is commonly used for the treatment of diseases involving a khapa and pitta doshas. Traditionally, C. intybus is used for the treatment of inflammatory...
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doaj-e84324b1eaca49af8de93b006d2afa8d2020-11-24T23:14:57ZengWolters Kluwer Medknow PublicationsAncient Science of Life0257-79412014-01-01341444910.4103/0257-7941.150780Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activityWaseem RizviMohd. FayazuddinSyed ShariqOmpal SinghShagufta MoinKafil AkhtarAnil KumarBackground: Cichorium intybus L. commonly known as chicory is one of the important medicinal plants commonly used in Ayurvedic system of medicine. It is commonly used for the treatment of diseases involving a khapa and pitta doshas. Traditionally, C. intybus is used for the treatment of inflammatory conditions, but there are only few in vitro studies reporting the anti-inflammatory activity of roots of chicory. Objective: Evaluation of anti-inflammatory activity of roots of chicory and mechanisms involved in it using in vivo models of inflammation. Materials and Methods: Albino Wistar rats of either sex weighing 150-200 g were used. Ethanolic and aqueous extracts of roots of chicory were prepared with the help of Soxhlet′s apparatus. The anti-inflammatory activity was studied using carrageenan-induced paw edema method and cotton pellet granuloma method. Levels of cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and IL-1 and activity of antioxidant enzymes such as catalase (CAT) and glutathione peroxidase (GPx) were estimated. Results: Chicory roots demonstrated significant dose-dependent decrease in paw edema in carrageenan-induced paw edema method. Chicory roots diminished the serum TNF-α, IL-6, and IL-1 levels. They also significantly attenuated the malonylaldehyde levels and increased the activities of CAT and GPx in paw tissue. Similarly, chicory roots demonstrated a significant decrease in granuloma formation in cotton pellet induced granuloma method. Conclusion: Chicory roots possess anti-inflammatory activity, and this might be due to the inhibition of various cytokines, antioxidant effects, and their free radical scavenging activity.http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2014;volume=34;issue=1;spage=44;epage=49;aulast=RizviAnti-inflammatoryantioxidant activitycarrageenanCichorium intybuscytokines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Waseem Rizvi Mohd. Fayazuddin Syed Shariq Ompal Singh Shagufta Moin Kafil Akhtar Anil Kumar |
spellingShingle |
Waseem Rizvi Mohd. Fayazuddin Syed Shariq Ompal Singh Shagufta Moin Kafil Akhtar Anil Kumar Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity Ancient Science of Life Anti-inflammatory antioxidant activity carrageenan Cichorium intybus cytokines |
author_facet |
Waseem Rizvi Mohd. Fayazuddin Syed Shariq Ompal Singh Shagufta Moin Kafil Akhtar Anil Kumar |
author_sort |
Waseem Rizvi |
title |
Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity |
title_short |
Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity |
title_full |
Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity |
title_fullStr |
Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity |
title_full_unstemmed |
Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity |
title_sort |
anti-inflammatory activity of roots of cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity |
publisher |
Wolters Kluwer Medknow Publications |
series |
Ancient Science of Life |
issn |
0257-7941 |
publishDate |
2014-01-01 |
description |
Background: Cichorium intybus L. commonly known as chicory is one of the important medicinal plants commonly used in Ayurvedic system of medicine. It is commonly used for the treatment of diseases involving a khapa and pitta doshas. Traditionally, C. intybus is used for the treatment of inflammatory conditions, but there are only few in vitro studies reporting the anti-inflammatory activity of roots of chicory.
Objective: Evaluation of anti-inflammatory activity of roots of chicory and mechanisms involved in it using in vivo models of inflammation.
Materials and Methods: Albino Wistar rats of either sex weighing 150-200 g were used. Ethanolic and aqueous extracts of roots of chicory were prepared with the help of Soxhlet′s apparatus. The anti-inflammatory activity was studied using carrageenan-induced paw edema method and cotton pellet granuloma method. Levels of cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and IL-1 and activity of antioxidant enzymes such as catalase (CAT) and glutathione peroxidase (GPx) were estimated.
Results: Chicory roots demonstrated significant dose-dependent decrease in paw edema in carrageenan-induced paw edema method. Chicory roots diminished the serum TNF-α, IL-6, and IL-1 levels. They also significantly attenuated the malonylaldehyde levels and increased the activities of CAT and GPx in paw tissue. Similarly, chicory roots demonstrated a significant decrease in granuloma formation in cotton pellet induced granuloma method.
Conclusion: Chicory roots possess anti-inflammatory activity, and this might be due to the inhibition of various cytokines, antioxidant effects, and their free radical scavenging activity. |
topic |
Anti-inflammatory antioxidant activity carrageenan Cichorium intybus cytokines |
url |
http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2014;volume=34;issue=1;spage=44;epage=49;aulast=Rizvi |
work_keys_str_mv |
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