Complete remission of locally adComplete remission of locally advanced penile squamous cell carcinoma after multimodality treatment
Treatment of locally advanced penile squamous cell carcinoma (pSCC) remains highly controversial secondary to disease rarity and lack of prospective randomized controlled trials. The current mainstays of care are multimodality treatment with neoadjuvant chemotherapy and surgery. However, clinicians...
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doaj-e84d18201b01467a9346d26b696601282020-11-25T03:48:09ZengSAGE PublishingRare Tumors2036-36052036-36132016-12-018410.4081/rt.2016.66513596Complete remission of locally adComplete remission of locally advanced penile squamous cell carcinoma after multimodality treatmentYifan Meng0Helen Levey Bernie1Tzu-Hua Weng2Dean-An Ling3Edward M. Messing4Elizabeth Guancial5School of Medicine and Dentistry, University of Rochester, NYDepartment of Urology, University of Rochester, NYNational Taiwan University School of Medicine, TaipeiNational Taiwan University School of Medicine, TaipeiDepartment of Urology, University of Rochester, NYDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester, NYTreatment of locally advanced penile squamous cell carcinoma (pSCC) remains highly controversial secondary to disease rarity and lack of prospective randomized controlled trials. The current mainstays of care are multimodality treatment with neoadjuvant chemotherapy and surgery. However, clinicians often have difficulty making recommendations for patients unable to tolerate chemotherapy or surgery due to scarcity of data to guide clinical decision-making. We report two cases of locally advanced pSCC that achieved complete remission after treatment with cisplatin-based neoadjuvant chemotherapy and surgery in one case, and concurrent cisplatin chemoradiation in a second, supporting the use of chemotherapy as part of first-line multimodal therapy. We also discuss additional treatment options for patients unable to tolerate traditional chemotherapy regimens.http://www.pagepress.org/journals/index.php/rt/article/view/6651Neoadjuvant chemotherapyPenile squamous cell carcinomaCisplatinSurgeryChemoradiation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yifan Meng Helen Levey Bernie Tzu-Hua Weng Dean-An Ling Edward M. Messing Elizabeth Guancial |
spellingShingle |
Yifan Meng Helen Levey Bernie Tzu-Hua Weng Dean-An Ling Edward M. Messing Elizabeth Guancial Complete remission of locally adComplete remission of locally advanced penile squamous cell carcinoma after multimodality treatment Rare Tumors Neoadjuvant chemotherapy Penile squamous cell carcinoma Cisplatin Surgery Chemoradiation |
author_facet |
Yifan Meng Helen Levey Bernie Tzu-Hua Weng Dean-An Ling Edward M. Messing Elizabeth Guancial |
author_sort |
Yifan Meng |
title |
Complete remission of locally adComplete remission of locally advanced penile squamous cell carcinoma after multimodality treatment |
title_short |
Complete remission of locally adComplete remission of locally advanced penile squamous cell carcinoma after multimodality treatment |
title_full |
Complete remission of locally adComplete remission of locally advanced penile squamous cell carcinoma after multimodality treatment |
title_fullStr |
Complete remission of locally adComplete remission of locally advanced penile squamous cell carcinoma after multimodality treatment |
title_full_unstemmed |
Complete remission of locally adComplete remission of locally advanced penile squamous cell carcinoma after multimodality treatment |
title_sort |
complete remission of locally adcomplete remission of locally advanced penile squamous cell carcinoma after multimodality treatment |
publisher |
SAGE Publishing |
series |
Rare Tumors |
issn |
2036-3605 2036-3613 |
publishDate |
2016-12-01 |
description |
Treatment of locally advanced penile squamous cell carcinoma (pSCC) remains highly controversial secondary to disease rarity and lack of prospective randomized controlled trials. The current mainstays of care are multimodality treatment with neoadjuvant chemotherapy and surgery. However, clinicians often have difficulty making recommendations for patients unable to tolerate chemotherapy or surgery due to scarcity of data to guide clinical decision-making. We report two cases of locally advanced pSCC that achieved complete remission after treatment with cisplatin-based neoadjuvant chemotherapy and surgery in one case, and concurrent cisplatin chemoradiation in a second, supporting the use of chemotherapy as part of first-line multimodal therapy. We also discuss additional treatment options for patients unable to tolerate traditional chemotherapy regimens. |
topic |
Neoadjuvant chemotherapy Penile squamous cell carcinoma Cisplatin Surgery Chemoradiation |
url |
http://www.pagepress.org/journals/index.php/rt/article/view/6651 |
work_keys_str_mv |
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