Phosphatases of α-synuclein, LRRK2 and tau: important players in the phosphorylation-dependent pathology of Parkinsonism
An important challenge in the field of Parkinson’s disease is to develop disease modifying therapies capable of stalling or even halting disease progression. Coupled to this challenge is the need to identify disease biomarkers, in order to identify pre-symptomatic hallmarks of disease and monitor di...
Main Authors: | Jean-Marc eTaymans, Veerle eBaekelandt |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-11-01
|
Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00382/full |
Similar Items
-
Regulation and targeting of enzymes mediating Parkinson’s disease pathogenesis: focus on Parkinson’s disease kinases, GTPases and ATPases
by: Jean-Marc eTaymans, et al.
Published: (2014-07-01) -
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons
by: Jason Schapansky, et al.
Published: (2018-03-01) -
Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson’s Disease
by: Hu S, et al.
Published: (2020-03-01) -
LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?
by: Darren M. O’Hara, et al.
Published: (2020-06-01) -
The Evolution of Tau Phosphorylation and Interactions
by: Nataliya I. Trushina, et al.
Published: (2019-09-01)