Phylogeography of Puumala orthohantavirus in Europe
Puumala virus is an RNA virus hosted by the bank vole <i>(Myodes glareolus)</i> and is today present in most European countries. Whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, Puumala virus (PUUV) evolutionary history is still controvers...
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doaj-e854b8cc1a8f43d893e2f8c5ac42e1712020-11-24T21:24:08ZengMDPI AGViruses1999-49152019-07-0111867910.3390/v11080679v11080679Phylogeography of Puumala orthohantavirus in EuropeGuillaume Castel0François Chevenet1Maria Razzauti2Séverine Murri3Philippe Marianneau4Jean-François Cosson5Noël Tordo6Alexander Plyusnin7CBGP, INRA, CIRAD, IRD, Montpellier SupAgro, Université Montpellier, 34000 Montpellier, FranceMIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, FranceCBGP, INRA, CIRAD, IRD, Montpellier SupAgro, Université Montpellier, 34000 Montpellier, FranceANSES, Virology Unit, 69007 Lyon, FranceANSES, Virology Unit, 69007 Lyon, FranceBIPAR-INRA Biologie Moléculaire et Immunologie Parasitaires et Fongiques, ENVA Maisons Alfort, 7 Avenue du Général de Gaulle, 94704 Maisons-Alfort CEDEX, FranceInstitut Pasteur, Antiviral Strategies Unit, Department of Virology, Paris, France & Institut Pasteur de Guinée, BP 4416 Conakry, GuineaDepartment of Virology, University of Helsinki, 00014 Helsinki, FinlandPuumala virus is an RNA virus hosted by the bank vole <i>(Myodes glareolus)</i> and is today present in most European countries. Whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, Puumala virus (PUUV) evolutionary history is still controversial and so far has not been studied at the whole European level. This study attempts to reconstruct the phylogeographical spread of modern PUUV throughout Europe during the last postglacial period in the light of an upgraded dataset of complete PUUV small (S) segment sequences and by using most recent computational approaches. Taking advantage of the knowledge on the past migrations of its host, we identified at least three potential independent dispersal routes of PUUV during postglacial recolonization of Europe by the bank vole. From the Alpe-Adrian region (Balkan, Austria, and Hungary) to Western European countries (Germany, France, Belgium, and Netherland), and South Scandinavia. From the vicinity of Carpathian Mountains to the Baltic countries and to Poland, Russia, and Finland. The dissemination towards Denmark and North Scandinavia is more hypothetical and probably involved several independent streams from south and north Fennoscandia.https://www.mdpi.com/1999-4915/11/8/679puumala orthohantavirusphylogeographyco-evolutionbank vole (myodes glareolus) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guillaume Castel François Chevenet Maria Razzauti Séverine Murri Philippe Marianneau Jean-François Cosson Noël Tordo Alexander Plyusnin |
spellingShingle |
Guillaume Castel François Chevenet Maria Razzauti Séverine Murri Philippe Marianneau Jean-François Cosson Noël Tordo Alexander Plyusnin Phylogeography of Puumala orthohantavirus in Europe Viruses puumala orthohantavirus phylogeography co-evolution bank vole (myodes glareolus) |
author_facet |
Guillaume Castel François Chevenet Maria Razzauti Séverine Murri Philippe Marianneau Jean-François Cosson Noël Tordo Alexander Plyusnin |
author_sort |
Guillaume Castel |
title |
Phylogeography of Puumala orthohantavirus in Europe |
title_short |
Phylogeography of Puumala orthohantavirus in Europe |
title_full |
Phylogeography of Puumala orthohantavirus in Europe |
title_fullStr |
Phylogeography of Puumala orthohantavirus in Europe |
title_full_unstemmed |
Phylogeography of Puumala orthohantavirus in Europe |
title_sort |
phylogeography of puumala orthohantavirus in europe |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2019-07-01 |
description |
Puumala virus is an RNA virus hosted by the bank vole <i>(Myodes glareolus)</i> and is today present in most European countries. Whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, Puumala virus (PUUV) evolutionary history is still controversial and so far has not been studied at the whole European level. This study attempts to reconstruct the phylogeographical spread of modern PUUV throughout Europe during the last postglacial period in the light of an upgraded dataset of complete PUUV small (S) segment sequences and by using most recent computational approaches. Taking advantage of the knowledge on the past migrations of its host, we identified at least three potential independent dispersal routes of PUUV during postglacial recolonization of Europe by the bank vole. From the Alpe-Adrian region (Balkan, Austria, and Hungary) to Western European countries (Germany, France, Belgium, and Netherland), and South Scandinavia. From the vicinity of Carpathian Mountains to the Baltic countries and to Poland, Russia, and Finland. The dissemination towards Denmark and North Scandinavia is more hypothetical and probably involved several independent streams from south and north Fennoscandia. |
topic |
puumala orthohantavirus phylogeography co-evolution bank vole (myodes glareolus) |
url |
https://www.mdpi.com/1999-4915/11/8/679 |
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