Effect of Gundelia tournefortii L. on some cardiovascular risk factors in an animal model
Introduction: There is no certain result in the field of industrial pharmacy approaching to find effective drugs in prevention and treatment of atherosclerosis, like the control of lipid factors that are major risk factors of atherosclerosis. This study was designed to evaluate the effects of Gundel...
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doaj-e8563a22fc674808ab53d4ab53373ea12021-08-02T13:48:21ZengNikan Research InstituteJournal of HerbMed Pharmacology2345-50042017-10-0164191195JHP_20170924172806Effect of Gundelia tournefortii L. on some cardiovascular risk factors in an animal modelLaleh Rafiee0Mahtab Keshvari1Ahmad Movahedian Atar2Zahra Hamidzadeh3Gholam Reza Dashti4Mahmoud Rafieian-Kopaei5Sedigheh Asgary6Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranSchool of pharmacy and pharmaceutical research center, Isfahan University of Medical Sciences, Isfahan, IranPhysiology Research Centre, Isfahan University of Medical Sciences, Isfahan, IranPhysiology Research Centre, Isfahan University of Medical Sciences, Isfahan, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranIntroduction: There is no certain result in the field of industrial pharmacy approaching to find effective drugs in prevention and treatment of atherosclerosis, like the control of lipid factors that are major risk factors of atherosclerosis. This study was designed to evaluate the effects of Gundelia tournefortii on atherosclerosis biomarkers by measuring some biochemical factors and formation of fatty streaks. Methods: In this preclinical study, 20 male rabbits were randomly divided into 4 groups as normal diet, cholesterol diet, normal diet supplemented with G. tournefortii extract, and cholesterol diet supplemented with G. tournefortii extract. Fasting blood samples were taken at the first and end of the study. Lipoproteins, Apo lipoproteins, fasting blood sugar (FBS), low density lipoproteins (LDL), factor VII and C-reactive protein (CRP) were measured. For each animal, histopathology of right coronary artery, left coronary artery and aorta were also studied. Results: Significant decrease in the fatty streak formation was observed in the group receiving cholesterol-rich diet supplemented with G. tournefortii. There were not any significant changes in measured biochemical factors except for significant reduction in factor VII when G. tournefortii was supplemented with high cholesterol diet. Conclusion: Gundelia tournefortii decreases atherosclerosis in hypercholesterolemic diet especially by decreasing coagulating factors like factor VII. Hence, it might be beneficial in prevention of atherosclerosis.http://herbmedpharmacol.com/PDF/JHP_20170924172806Gundelia tournefortiiAtherosclerosisCholesterolFatty streak |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laleh Rafiee Mahtab Keshvari Ahmad Movahedian Atar Zahra Hamidzadeh Gholam Reza Dashti Mahmoud Rafieian-Kopaei Sedigheh Asgary |
spellingShingle |
Laleh Rafiee Mahtab Keshvari Ahmad Movahedian Atar Zahra Hamidzadeh Gholam Reza Dashti Mahmoud Rafieian-Kopaei Sedigheh Asgary Effect of Gundelia tournefortii L. on some cardiovascular risk factors in an animal model Journal of HerbMed Pharmacology Gundelia tournefortii Atherosclerosis Cholesterol Fatty streak |
author_facet |
Laleh Rafiee Mahtab Keshvari Ahmad Movahedian Atar Zahra Hamidzadeh Gholam Reza Dashti Mahmoud Rafieian-Kopaei Sedigheh Asgary |
author_sort |
Laleh Rafiee |
title |
Effect of Gundelia tournefortii L. on some cardiovascular risk factors in an animal model |
title_short |
Effect of Gundelia tournefortii L. on some cardiovascular risk factors in an animal model |
title_full |
Effect of Gundelia tournefortii L. on some cardiovascular risk factors in an animal model |
title_fullStr |
Effect of Gundelia tournefortii L. on some cardiovascular risk factors in an animal model |
title_full_unstemmed |
Effect of Gundelia tournefortii L. on some cardiovascular risk factors in an animal model |
title_sort |
effect of gundelia tournefortii l. on some cardiovascular risk factors in an animal model |
publisher |
Nikan Research Institute |
series |
Journal of HerbMed Pharmacology |
issn |
2345-5004 |
publishDate |
2017-10-01 |
description |
Introduction: There is no certain result in the field of industrial pharmacy approaching to find effective drugs in prevention and treatment of atherosclerosis, like the control of lipid factors that are major risk factors of atherosclerosis. This study was designed to evaluate the effects of Gundelia tournefortii on atherosclerosis biomarkers by measuring some biochemical factors and formation of fatty streaks. Methods: In this preclinical study, 20 male rabbits were randomly divided into 4 groups as normal diet, cholesterol diet, normal diet supplemented with G. tournefortii extract, and cholesterol diet supplemented with G. tournefortii extract. Fasting blood samples were taken at the first and end of the study. Lipoproteins, Apo lipoproteins, fasting blood sugar (FBS), low density lipoproteins (LDL), factor VII and C-reactive protein (CRP) were measured. For each animal, histopathology of right coronary artery, left coronary artery and aorta were also studied. Results: Significant decrease in the fatty streak formation was observed in the group receiving cholesterol-rich diet supplemented with G. tournefortii. There were not any significant changes in measured biochemical factors except for significant reduction in factor VII when G. tournefortii was supplemented with high cholesterol diet. Conclusion: Gundelia tournefortii decreases atherosclerosis in hypercholesterolemic diet especially by decreasing coagulating factors like factor VII. Hence, it might be beneficial in prevention of atherosclerosis. |
topic |
Gundelia tournefortii Atherosclerosis Cholesterol Fatty streak |
url |
http://herbmedpharmacol.com/PDF/JHP_20170924172806 |
work_keys_str_mv |
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