Estimation of 24-Hour Intraocular Pressure Peak Timing and Variation Using a Contact Lens Sensor.
To compare estimates of 24-hour intraocular pressure (IOP) peak timing and variation obtained using a contact lens sensor (CLS) and using a pneumatonometer.Laboratory data collected from 30 healthy volunteers (ages, 20-66 years) in a randomized, controlled clinical trial were analyzed. Participants...
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2015-01-01
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doaj-e8700497b66c442b8106b7e3923b00812020-11-25T02:29:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012952910.1371/journal.pone.0129529Estimation of 24-Hour Intraocular Pressure Peak Timing and Variation Using a Contact Lens Sensor.John H K LiuKaweh MansouriRobert N WeinrebTo compare estimates of 24-hour intraocular pressure (IOP) peak timing and variation obtained using a contact lens sensor (CLS) and using a pneumatonometer.Laboratory data collected from 30 healthy volunteers (ages, 20-66 years) in a randomized, controlled clinical trial were analyzed. Participants were housed for 24 hours in a sleep laboratory. One randomly selected right or left eye was fitted with a CLS that monitored circumferential curvature in the corneoscleral region related to the change of IOP. Electronic output signals of 30 seconds were averaged and recorded every 5 minutes. In the contralateral eye, habitual IOP measurements were taken using a pneumatonometer once every two hours. Simulated 24-hour rhythms in both eyes were determined by cosinor fitting. Simulated peak timings (acrophases) and simulated data variations (amplitudes) were compared between the paired eyes.Bilateral change patterns of average 24-hour data for the group were in parallel. The simulated peak timing in the CLS fitted eye occurred at 4:44 AM ± 210 min (mean ± SD) and the IOP peak timing in the contralateral eye at 4:11 AM ± 120 min (P=0.256, Wilcoxon signed-rank test). There was no significant correlation between the simulated data variations in the paired eyes (P=0.820, linear regression).The 24-hour CLS data showed a simulated peak timing close to the 24-hour IOP peak timing obtained using the pneumatonometer. However, the simulated variations of 24-hour data in the paired eyes were not correlated. Estimated 24-hour IOP rhythms using the two devices should not be considered interchangeable.http://europepmc.org/articles/PMC4468106?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
John H K Liu Kaweh Mansouri Robert N Weinreb |
spellingShingle |
John H K Liu Kaweh Mansouri Robert N Weinreb Estimation of 24-Hour Intraocular Pressure Peak Timing and Variation Using a Contact Lens Sensor. PLoS ONE |
author_facet |
John H K Liu Kaweh Mansouri Robert N Weinreb |
author_sort |
John H K Liu |
title |
Estimation of 24-Hour Intraocular Pressure Peak Timing and Variation Using a Contact Lens Sensor. |
title_short |
Estimation of 24-Hour Intraocular Pressure Peak Timing and Variation Using a Contact Lens Sensor. |
title_full |
Estimation of 24-Hour Intraocular Pressure Peak Timing and Variation Using a Contact Lens Sensor. |
title_fullStr |
Estimation of 24-Hour Intraocular Pressure Peak Timing and Variation Using a Contact Lens Sensor. |
title_full_unstemmed |
Estimation of 24-Hour Intraocular Pressure Peak Timing and Variation Using a Contact Lens Sensor. |
title_sort |
estimation of 24-hour intraocular pressure peak timing and variation using a contact lens sensor. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
To compare estimates of 24-hour intraocular pressure (IOP) peak timing and variation obtained using a contact lens sensor (CLS) and using a pneumatonometer.Laboratory data collected from 30 healthy volunteers (ages, 20-66 years) in a randomized, controlled clinical trial were analyzed. Participants were housed for 24 hours in a sleep laboratory. One randomly selected right or left eye was fitted with a CLS that monitored circumferential curvature in the corneoscleral region related to the change of IOP. Electronic output signals of 30 seconds were averaged and recorded every 5 minutes. In the contralateral eye, habitual IOP measurements were taken using a pneumatonometer once every two hours. Simulated 24-hour rhythms in both eyes were determined by cosinor fitting. Simulated peak timings (acrophases) and simulated data variations (amplitudes) were compared between the paired eyes.Bilateral change patterns of average 24-hour data for the group were in parallel. The simulated peak timing in the CLS fitted eye occurred at 4:44 AM ± 210 min (mean ± SD) and the IOP peak timing in the contralateral eye at 4:11 AM ± 120 min (P=0.256, Wilcoxon signed-rank test). There was no significant correlation between the simulated data variations in the paired eyes (P=0.820, linear regression).The 24-hour CLS data showed a simulated peak timing close to the 24-hour IOP peak timing obtained using the pneumatonometer. However, the simulated variations of 24-hour data in the paired eyes were not correlated. Estimated 24-hour IOP rhythms using the two devices should not be considered interchangeable. |
url |
http://europepmc.org/articles/PMC4468106?pdf=render |
work_keys_str_mv |
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