Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon
Abstract Background Parasite infections can have substantial impacts on population dynamics and are accordingly a key challenge for wild population management. Here we studied genetic mechanisms driving parasite resistance in a large herbivore through a comprehensive approach combining measurements...
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doaj-e8795cea5e284def9e7d687f7c98ee352021-09-02T10:58:47ZengBMCBMC Ecology1472-67852019-03-0119111410.1186/s12898-019-0228-xBoth candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflonElodie Portanier0Mathieu Garel1Sébastien Devillard2Daniel Maillard3Jocelyn Poissant4Maxime Galan5Slimania Benabed6Marie-Thérèse Poirel7Jeanne Duhayer8Christian Itty9Gilles Bourgoin10Univ Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire de Biométrie et Biologie ÉvolutiveOffice National de la Chasse et de la Faune Sauvage, Unité Ongulés SauvagesUniv Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire de Biométrie et Biologie ÉvolutiveOffice National de la Chasse et de la Faune Sauvage, Unité Ongulés SauvagesDepartment of Ecosystem and Public Health, University of CalgaryCBGP, INRA, CIRAD, IRD, Montpellier SupAgro, Université de MontpellierUniversité de Lyon, VetAgro Sup, Campus Vétérinaire de LyonUniversité de Lyon, VetAgro Sup, Campus Vétérinaire de LyonOffice National de la Chasse et de la Faune Sauvage, Unité Ongulés SauvagesOffice National de la Chasse et de la Faune Sauvage, Unité Ongulés SauvagesUniv Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire de Biométrie et Biologie ÉvolutiveAbstract Background Parasite infections can have substantial impacts on population dynamics and are accordingly a key challenge for wild population management. Here we studied genetic mechanisms driving parasite resistance in a large herbivore through a comprehensive approach combining measurements of neutral (16 microsatellites) and adaptive (MHC DRB1 exon 2) genetic diversity and two types of gastrointestinal parasites (nematodes and coccidia). Results While accounting for other extrinsic and intrinsic predictors known to impact parasite load, we show that both neutral genetic diversity and DRB1 are associated with resistance to gastrointestinal nematodes. Intermediate levels of multi-locus heterozygosity maximized nematodes resistance, suggesting that both in- and outbreeding depression might occur in the population. DRB1 heterozygosity and specific alleles effects were detected, suggesting the occurrence of heterozygote advantage, rare-allele effects and/or fluctuating selection. On the contrary, no association was detected between genetic diversity and resistance to coccidia, indicating that different parasite classes are impacted by different genetic drivers. Conclusions This study provides important insights for large herbivores and wild sheep pathogen management, and in particular suggests that factors likely to impact genetic diversity and allelic frequencies, including global changes, are also expected to impact parasite resistance.http://link.springer.com/article/10.1186/s12898-019-0228-xHeterozygosity-fitness correlationsImmunocompetenceMHCGastro-intestinal nematodesCoccidia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elodie Portanier Mathieu Garel Sébastien Devillard Daniel Maillard Jocelyn Poissant Maxime Galan Slimania Benabed Marie-Thérèse Poirel Jeanne Duhayer Christian Itty Gilles Bourgoin |
spellingShingle |
Elodie Portanier Mathieu Garel Sébastien Devillard Daniel Maillard Jocelyn Poissant Maxime Galan Slimania Benabed Marie-Thérèse Poirel Jeanne Duhayer Christian Itty Gilles Bourgoin Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon BMC Ecology Heterozygosity-fitness correlations Immunocompetence MHC Gastro-intestinal nematodes Coccidia |
author_facet |
Elodie Portanier Mathieu Garel Sébastien Devillard Daniel Maillard Jocelyn Poissant Maxime Galan Slimania Benabed Marie-Thérèse Poirel Jeanne Duhayer Christian Itty Gilles Bourgoin |
author_sort |
Elodie Portanier |
title |
Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon |
title_short |
Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon |
title_full |
Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon |
title_fullStr |
Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon |
title_full_unstemmed |
Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon |
title_sort |
both candidate gene and neutral genetic diversity correlate with parasite resistance in female mediterranean mouflon |
publisher |
BMC |
series |
BMC Ecology |
issn |
1472-6785 |
publishDate |
2019-03-01 |
description |
Abstract Background Parasite infections can have substantial impacts on population dynamics and are accordingly a key challenge for wild population management. Here we studied genetic mechanisms driving parasite resistance in a large herbivore through a comprehensive approach combining measurements of neutral (16 microsatellites) and adaptive (MHC DRB1 exon 2) genetic diversity and two types of gastrointestinal parasites (nematodes and coccidia). Results While accounting for other extrinsic and intrinsic predictors known to impact parasite load, we show that both neutral genetic diversity and DRB1 are associated with resistance to gastrointestinal nematodes. Intermediate levels of multi-locus heterozygosity maximized nematodes resistance, suggesting that both in- and outbreeding depression might occur in the population. DRB1 heterozygosity and specific alleles effects were detected, suggesting the occurrence of heterozygote advantage, rare-allele effects and/or fluctuating selection. On the contrary, no association was detected between genetic diversity and resistance to coccidia, indicating that different parasite classes are impacted by different genetic drivers. Conclusions This study provides important insights for large herbivores and wild sheep pathogen management, and in particular suggests that factors likely to impact genetic diversity and allelic frequencies, including global changes, are also expected to impact parasite resistance. |
topic |
Heterozygosity-fitness correlations Immunocompetence MHC Gastro-intestinal nematodes Coccidia |
url |
http://link.springer.com/article/10.1186/s12898-019-0228-x |
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